Melanosis of the esophagus

Pava, Samuel de la; Nigogosyan, G.; Pickren, John W.; Cabrera, Aurelio

doi:10.1002/1097-0142(196301)16:1<48::aid-cncr2820160107>3.0.co;2-m

Cited by 205 publications

(94 citation statements)

References 12 publications

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“…This phenomenon was first described in 1963 by De la Pava, who found melanocytes in 4% of his autopsy material from the esophagus [1] . Subsequent studies showed that the incidence of esophageal melanocytes ranges 2.5%-8% [2,3] .…”

Section: Introductionmentioning

confidence: 82%

“…In the normal human esophagus, scattered melanocytes may occur at the epithelio-stromal junction. In 1963, Dela Pava first described pre-existing esophageal melanocytes found in 4 out of 100 autopsies and found that they are not related to esophageal disorders [1] . I n t h e n o r m a l e s o p h a g u s , t h e n u m b e r o f intramucosal melanocytes is low and their presence can easily be overlooked, but many pathologic conditions can increase the number of melanocytes at the epitheliostromal junction [4] , suggesting that proliferation of melanocytes is based on pre-existing melanocytes in the interface between epithelium and underlying stroma.…”

Section: Discussionmentioning

confidence: 99%

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Coexistence of esophageal blue nevus, hair follicles and basaloid sqamous carcinoma: A case report

Wang¹,

Li²,

Gao³

et al. 2008

WJG

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We present the case of a 57-year-old man who underwent esophagectomy for esophageal carcinoma found at barium meal and gastroscopic examination. He was diagnosed as esophageal basaloid squamous carcinoma (BSC) and gastric stromal tumor, which were associated with focal proliferation of melanocytes/ pigmentophages and hair follicles in esophageal mucosa. Melanocytic hyperplasia (melanocytosis) has previously been recognized as an occasional reactive lesion, which can accompany esophageal inflammation and invasive squamous carcinoma. The present case is unusual because of its hyperplasia of not only melanocytes but also hair follicles. To our knowledge, this is the first report of esophageal blue nevus and hair follicle coexisting with BSC.

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Section: Introductionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Coexistence of esophageal blue nevus, hair follicles and basaloid sqamous carcinoma: A case report

Wang¹,

Li²,

Gao³

et al. 2008

WJG

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“…Diagnosis remained uncertain until benign melanocytes were found in the esophageal mucosa in 4 of 100 autopsies by Pava et al (3). Later, Ohashi (4) and colleagues acknowledged this observation by showing the presence of melanocytes in the esophageal mucosa of 8% of the population.…”

Section: Discussionmentioning

confidence: 99%

Primary esophageal melanoma: Report of a case

et al. 2016

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Introduction: Primary malignant melanoma of the esophagus is a rare tumor representing only 0.1-0.2% of esophageal malignancies. The goal of the study was to report on the management of a new case diagnosed and treated in our site.Case report: A 67-year-old patient presented with dysphagia to solids with no other remarkable history or associated skin lesions. He underwent gastroscopy, which revealed a polypoid mass suggestive of neoplasm in the distal third of the esophagus. Biopsy indicated melanoma with positive immunohistochemical markers S100 and HMB45, and negative cytokeratins and CEA. Computerized tomography (CT) and positron-emission tomography (PET) scans showed no local infiltration or distant metastases. An Ivor-Lewis esophagectomy procedure was performed with regional lymphadenectomy. Postoperative stay lasted for three weeks, and no remarkable postsurgical complications arose. The pathological study of the specimen confirmed the diagnosis of primary esophageal melanoma.Discussion: Primary malignant melanoma of the esophagus has an unfortunate prognosis as it is an aggressive tumor usually diagnosed at an advanced stage, with local invasion and metastatic disease. Currently, surgery is the treatment of choice, with the remaining adjuvant therapies obtaining limited results.Key words: Primary melanoma of esophagus. Metastasis. Treatment. CASE REPORTA 67-year-old patient presents with clinical dysphagia, predominantly to solids, for the past two months, with no associated vomiting or constitutional syndrome. His history is remarkable for psoriasis, smoking, and alcohol abuse. No adenopathies could be palpated in accessible regions, his abdomen was soft, non-tender, and depressible, and no masses or organomegalies could be identified. No malignancy-suggestive skin lesions were seen.As a part of the study a gastroscopy was performed, which revealed a pigmented, villous, ulcerated, pediculated polypoid lesion in the distal esophagus, which was friable to the touch and did not block the esophageal lumen. Biopsy samples were taken, which were consistent with squamous-cell melanoma positive for immunohistochemical markers S100 and HMB45, and negative for carcinoembryonic antigen (CEA) and cytokeratins.The extension study was completed with a chest-abdominal CT scan, which revealed an endoluminal esophageal growth compatible with neoplasm at the distal third of the esophagus, in the absence of either local infiltration or distant metastases evidence (Fig. 1).A TEP scan was ordered, which showed hypermetabolism at the distal third of the esophagus and no metastatic uptake suggestive of tumor infiltration. A diagnosis of primary esophageal melanoma was then reached by exclusion.Received: 01-07-2016 Accepted: 21-07-2016Correspondence: Laura Granel-Villach. Department of General and Digestive Surgery. Hospital General de Castellón. Avda. Benicássim, s/n. 12004 Castellón, Spain e-mail: laura_9487@yahoo.es. Granel-Villach L, Moya-Sanz MA, Escrig-Sos VJ, Fortea-Sanchís C, Martínez-Lahuerta C, Tornador-Gaya N...

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“…tarafından tanımlanmıştır (6). Etiyolojisi ve doğal seyri net olarak bilinmemesine karşın primer özofagial melanomaların prekürsör lezyonları olabileceği bildirilmektedir (1,(4)(5)(6).…”

Section: Discussionunclassified

Melanocytosis of the oesophagus: case report

Ünverdǐ¹,

Savaş²,

Ensarı³

et al. 2012

TJPATH

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Esophageal melanocytosis is a benign clinicopathologic entity characterized by melanocytic proliferation in esophageal squamous epithelium and melanin deposition in the mucosa. Little is known about the etiology and natural course of this condition, although it has been suggested to be a precursor of primary esophageal melanoma by some authors. Following a search of the databases regarding esophageal melanocytosis and melanosis, thirty-four cases of isolated esophageal melanocytosis were found. The histopathologic features of esophageal melanocytosis are reviewed and its differential diagnosis with other pigmented esophageal lesions is discussed. Key Words: Esophagus, Melanosis, Melanoma ÖZÖzofagial melanozis özofagus skuamöz epitelinde melanositik proliferasyon ve mukozada melanin birikimi ile giden benign klinikopatolojik bir antitedir. Etiyolojisi ve doğal seyri net olarak bilinmemesine karşın bazı yazarlar tarafından primer özofagial melanomaların öncü lezyonları olabileceği belirtilmiştir. Oldukça nadir görülen bir antite olan özofagial melanozis ardışık yapılan gastrointestinal endoskopiler sırasında %0,07-2,1 oranında bildirilmesine karşın otopsi materyallerinde daha sık olarak görülmektedir. Şimdiye kadar literatürde 34 olgu bildirilmiştir. Bunların büyük çoğunluğu Asya ve Doğu Asya kökenlidir. Batı ülkelerinde çok daha az oranda görülmektedir. Olgular arasında yaş ve cinsiyet ayırımı bulunmamaktadır. Burada nadir görülen bir antite olan özofagial melanozis tanısı alan 3 ayrı olgu literatür bilgileri eşliğinde sunulmaktadır.

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Melanosis of the esophagus

Cited by 205 publications

References 12 publications

Coexistence of esophageal blue nevus, hair follicles and basaloid sqamous carcinoma: A case report

Coexistence of esophageal blue nevus, hair follicles and basaloid sqamous carcinoma: A case report

Primary esophageal melanoma: Report of a case

Melanocytosis of the oesophagus: case report

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