Clostridial gas gangrene and septicemia in malignant disease

Cabrera, Aurelio; Tsukada, Yoshiaki; Pickren, John W.

doi:10.1002/1097-0142(196507)18:7<800::aid-cncr2820180704>3.0.co;2-a

Cited by 72 publications

(16 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…can localise and germinate in neoplasms and produce extensive lysis of tumours without concomitant effect on normal tissue (Malmgren and Flanigan, 1955), and clostridial septicaemia originating from an infection within tumour lesions has been reported (Cabrera et al, 1965;Alpern and Dowell, 1969;Caya et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Bacteria from solid tumours

Brook

1990

Journal of Medical Microbiology

View full text Add to dashboard Cite

Summary. Bacteria were grown from 63 (69%) of 9 1 specimens from necrotic tumours in 63 patients. Of the tumours, 14 were abdominal, 5 pelvic, 23 of the head and neck, 4 of the lungs, 4 mediastinal, 2 lymphatic, 3 of the breast, and 8 were miscellaneous. Aerobic or facultatively anaerobic bacteria only were present in 12 (1 9%) specimens, anaerobes only in 10 (16%), and mixed aerobic and anaerobic bacteria in 41 (65%). A total of 83 anaerobic and 47 aerobic and facultatively anaerobic bacteria were isolated. The predominant anaerobic bacteria were Bacteroides spp. (36 isolates), and anaerobic cocci (2 1) and Propionibacterium acnes (22). The aerobic and facultatively anaerobic bacteria most frequently isolated were Staphylococcus aureus, a-haemolytic streptococci , Escherichia coli (seven isolates each), S . epidermidis, Klebsiella pneumoniae and Pseudomonas aeruginosa (five isolates each). These data demonstrate that infection of tumours is usually polymicrobial.

show abstract

Section: Discussionmentioning

confidence: 99%

Bacteria from solid tumours

Brook

1990

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…Nine of the 10 patients reviewed by Jendrzejewski et al (1978) presented debilitated states or malignancies. Cancer as well as cytostatic and immunosuppressive therapy are often cited as predisposing factors to Clostridium septicaemia (Smucker, Reid and Harding, 1960;Cabrera, Tsukada and Pickren, 1965;Wynne and Armstrong, 1972;Mzabi, et al, 1975). In addition to the epithelial break due to the neoplasia or its treatment, the metabolic and immunological changes associated with neoplasia may contribute to create a local environment favourable to infection.…”

Section: Discussionmentioning

confidence: 99%

Non-traumatic clostridial myositis: an unusual feature of brain death

Thys

Ectors

Noël

1980

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

“…It is interesting to speculate from these data whether the thrombotic occlusion of the hepatic artery as a complication of hepatic artery catheterization in case 1 and the presence of an indwelling hepatic catheter in cases 2 and 3 provided a favorable hypoxic background for the ultimate growth of Clostridium. Clostridium septicemia has been reported in association with malignant disease, but it appears that damaged tissue is needed as a background prior to growth [16,17]. A recent report indicates an increased survival of patients with liver metastases when dearterialization of the liver coupled with intraportal infusion chemotherapy is done instead of arterial infusion alone [18].…”

Section: Discussionmentioning

confidence: 99%