Bacteria from solid tumours

Brook, Itzhak

doi:10.1099/00222615-32-3-207

Cited by 14 publications

(9 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An innovative approach for tumour-speci¢c delivery of therapeutic proteins is to use bacterial vector systems [2^4]. Infections with anaerobic bacteria can spontaneously occur in rodent as well as in human tumours [5,6]. Tumours can also be infected by systemic injections of spores of anaerobic bacteria, as shown both in rodent tumours [7] and in cancer patients in clinical trials [8].…”

Section: Introductionmentioning

confidence: 99%

Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas

Theys

2001

FEMS Immunology and Medical Microbiology

View full text Add to dashboard Cite

Previous studies have demonstrated the feasibility of using apathogenic clostridia as a promising strategy for hypoxia-specific tumour targeting. The present study shows that the use of the vascular targeting compound combretastatin A-4 phosphate could significantly (P<0.001) increase the number of Clostridium vegetative cells in rat rhabdomyosarcomas with sizes between 0.2 cm(2) and 3 cm(2). Furthermore, this study showed that administration of metronidazole for a 9-day period was sufficient to eliminate systemically administered Clostridium from the tumour. Moreover, previous Clostridium spore administration did not effect tumour colonisation, regardless of the immune response status of the host.

show abstract

Section: Introductionmentioning

confidence: 99%

Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas

Theys

2001

FEMS Immunology and Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…Anaerobic bacteria were recovered from 51 of 63 (85%) of necrotic tumor, 10 of 63 (16%) as the only isolate [8]. The predominant anaerobic bacteria were Bacteroides spp.…”

Section: Discussionmentioning

confidence: 97%

“…(36 isolates), anaerobic cocci [21] and P. acnes [22]. The recovery of anaerobic bacteria from infected tumors is not surprising, because when tumors outgrow their blood supply and become necrotic, the resulting lowered oxygen tension may favor the growth of anaerobes [8].…”

Section: Discussionmentioning

confidence: 99%

Aerobic and anaerobic infection associated with malignancy

Brook

Frazier

1998

Support Care Cancer

Self Cite

View full text Add to dashboard Cite

The goal of this work was to study the microbiology and clinical characteristics of patients with infections associated with malignancy treated over a period of 17 years. A total of 668 specimens were obtained from 605 patients. The malignancies include 224 hematological malignancies and 381 nonhematogenic malignancies. Anaerobic bacteria only were isolated in 201 (30%) specimens, aerobic bacteria in 226 (34%), mixed aerobic-anaerobic bacteria in 231 (35%) and Candida spp. in 10 (1%). A total of 683 anaerobic (1.0 isolates per specimens) and 592 aerobic or facultative (0.9 per specimen) organisms were recovered. The predominant anaerobic bacteria included Bacteroides fragilis group isolates (181), Peptostreptococcus spp. (166), Prevotella spp. (106), Clostridium spp. (70), and Fusobacterium spp. (43). The predominant aerobic bacteria included Escherichia coli (133), Staphylococcus aureus (100), Klebsiella pneumoniae (48), and Pseudomonas aeroginosa (45). The type of infections included abscesses (221), bacteremia (198), wounds (175), including 61 cellulitis, 24 post-surgical wounds and 23 decubitus ulcers), peritonitis (48), empyema (12), cholecystitis (6) and thrombophlebitis (5). S. aureus and Peptostreptococcus spp. were isolated from all sites. However, organisms of the oropharyngeal flora (Prevotella and Fusobacterium spp.) predominated in local infections and bacteremia that originated from this site (head and neck wounds and abscesses and pulmonary infections), and organisms of the gastrointestinal tract flora predominated in infections that originated from this site (peritonitis, abdominal abscesses and decubitus ulcers). This retrospective study demonstrates polymicrobial features of many infections associated with malignancies.

show abstract

“…Most infections were mixed, yielding both anaerobes and aerobes. Brook (1990) reviewed his experience in culturing necrotic tumours for aerobic and anaerobic bacteria over a period of 10 years. There were 282 bacteria isolates, and anaerobic bacteria accounted for 179 (63%).…”

Section: Microbiologymentioning

confidence: 99%

Microbiology and management of infected solid tumours

Brook

2007

Eur J Cancer Care

Self Cite

View full text Add to dashboard Cite

Infection has been recognized as one of the major obstacles to the successful management of patients with malignant tumours. Aerobic and anaerobic bacteria of endogenous source are a major cause of infections in the necrotic tumour, especially when they occur in proximity to a site where these bacteria reside as part of the normal flora. Although surgical removal or evacuation of the purulent fluid is preferred, this is not always feasible in a patient with a malignant tumour. Antimicrobial therapy against potential bacterial pathogens is often the sole therapy or is used along with surgical drainage or removal of the infected area. This review describes the microbiology and management of infection in necrotic tumours.

show abstract

Bacteria from solid tumours

Cited by 14 publications

References 16 publications

Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas

Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas

Aerobic and anaerobic infection associated with malignancy

Microbiology and management of infected solid tumours

Contact Info

Product

Resources

About