A 25-year-old, with type I Diabetes Mellitus with a previous diagnosis of Protamine Allergy but not to human Insulin, started to notice anaphylactic reactions inmmediatly after bolus with Insulin. Skin prick and intradermal test were positive to all insulins. Skin tests to other potential allergens resulted negative. Examination after bolus of Human Insulin revealed urticaria. Daily insulin requirement were around 2-2,4 U/Kg/day. Slow desensitisation with Aspart insulin, the insulin with lowest size of skin test, was performed using subcutaneous insulin pump. Six months after the end of desensitisation his daily insulin requirement decreased to 0.8 U/Kg/day and oral corticosteroids are being reduced with no symptoms.

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El presente artículo analiza la producción científica sobre turismo y covid-19 en la base de datos Scopus. Estudio exploratoriodescriptivo con diseño retrospectivo, cuyo marco temporal es el periodo 2019-2021. El procedimiento incluyó, en un primer momento, la definición de palabras clave para realizar una búsqueda genérica, seguido por la normalización a través del gestor bibliográfico EndNote X9 y, por último, el análisis de la información a través de Bibexcel versión 2016-02-20, Excel 2013, PAJEK y VOS viewer. Se identificaron 483 trabajos publicados de los cuales la mayoría (72,26%) son artículos académicos. Las revistas que más trabajos han publicado son Tourism Geographies, Sustainability Switzerland y Current Issues in Tourism. Por países, instituciones de Estados Unidos, Reino Unido y China lideran la producción científica en este tema. Las temáticas en las investigaciones estudiadas evidencian una evolución similar a las fases de la pandemia a nivel internacional.

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Patients infected by SARS-CoV-2 may develop pneumonia (COVID19) and require hospital admission and, eventually, critical care [1]. This has been related with a weaker innate immune response with impaired production of type I interferons [2]. In this setting, an antigen specific T-cell response is needed for the elimination of SARS-CoV-2, as well as to develop long-lasting memory to respond to potential future SARS-CoV-2 infections [3, 4]. However, this response needs to be contained once the virus is eradicated to avoid further damaging the host.

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