6.116 Monocyte Activation Markers in Obsessive-Compulsive Disorder

Morer, Àstrid; Rodriguez-Ferret, Natalia; Gonzalez, António; Gassó, Patricia; Serra-Pagès, Carles; Mas, Sergi; Lázaro, Luisa

doi:10.1016/j.jaac.2016.09.433

Cited by 1 publication

(2 citation statements)

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“…68 This may be further supported by the finding in patients with earlyonset OCD revealing increased production of inflammatory cytokines by monocytes when stimulated with lipopolysaccharide (LPS) or dexamethasone and LPS. 69 As such, patients with OCD may possess an intrinsic vulnerability to monocyte activation, which may generate an increased inflam-matory response. 69 In adult populations, results of studies investigating cytokines are inconsistent; however, many believe that this may be consequent to the confounding effects of medications and comorbid conditions (specifically mood disorders, which have been associated with low-grade inflammation) in study populations.…”

Section: Immune Dysregulationmentioning

confidence: 99%

“…69 As such, patients with OCD may possess an intrinsic vulnerability to monocyte activation, which may generate an increased inflam-matory response. 69 In adult populations, results of studies investigating cytokines are inconsistent; however, many believe that this may be consequent to the confounding effects of medications and comorbid conditions (specifically mood disorders, which have been associated with low-grade inflammation) in study populations. For example, a meta-analysis revealed decreased levels of IL-1 beta while showing no differences in levels of IL-6 and TNF-alpha between cases and controls, suggesting a noninflammatory profile.…”

Section: Immune Dysregulationmentioning

confidence: 99%

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An Update on the Relationship Between the Gut Microbiome and Obsessive-Compulsive Disorder

Turna¹,

Patterson²,

Ameringen³

2017

Psychiatric Annals

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The gut microbiome, the collection of microbes and their genetic material in the human gastrointestinal tract, has recently become a topic of interest in psychiatry. To date, animal studies have repeatedly shown behavior to be affected by alterations in the gut microbiota. Furthermore, studies in clinical psychiatric populations have also illustrated that microbial dysbiosis may play a role in these conditions, but results have been inconsistent. Given the existing animal and human literature providing evidence for a role of the microbiome in anxiety and depressive disorders, this review explores and develops similar lines of evidence in obsessive-compulsive disorder. Theoretical treatment options targeting the gut microbiome are also discussed.

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Section: Immune Dysregulationmentioning

confidence: 99%

Section: Immune Dysregulationmentioning

confidence: 99%