The kaeA(KAE1) (suDpro) gene, which was identified in Aspergillus nidulans as a suppressor of proline auxotrophic mutations, encodes the orthologue of Saccharomyces cerevisiae Kae1p, a member of the evolutionarily conserved KEOPS/EKC (Kinase, Endopeptidase and Other Proteins of Small size/Endopeptidase-like and Kinase associated to transcribed Chromatin) complex. In yeast, this complex has been shown to be involved in tRNA modification, transcription, and genome maintenance. In A. nidulans, mutations in kaeA result in several phenotypic effects, the derepression of arginine catabolism genes, and changes in the expression levels of several others, including genes involved in amino acid and siderophore metabolism, sulfate transport, carbon/energy metabolism, translation, and transcription regulation, such as rcoA(TUP1), which encodes the global transcriptional corepressor.
The arginase structural gene (agaA) from Aspergillus nidulans has been cloned and characterised. Depending on the growth conditions of the mycelium, transcripts of this gene have different 5'ends. These differences could result either from the presence of multiple transcription initiation sites or from differential processing of mRNA. The agaA mRNA has a long 5'UTR with a potentially complex secondary structure. Putative arginine binding aptamers were found in this UTR suggesting interesting possibilities for regulation of the agaA expression.
The paper is of investigative character for
elaborating cooperation standards between museums and
educational institutions. It aims at presenting and interpreting
the results of the Museum’s own research of the Face
Culture Project implemented in 2017–2019 at the National
Museum in Cracow. The analysis of the factors favouring and
impeding cooperation of museum and school has become
the basis for a wider generalization and shaping models of
museum and school learning in which the following elements
have been distinguished: goals, subjects, objects, means,
methods, conditions, and results. These elements have
been presented from the perspective of both museum and
school. The paper may prove of interest to school teachers
and museum educators cooperating with schools, as well as
to theoreticians of museology and of museum pedagogy, the
latter developing as a subdiscipline of pedagogy.
StreszczenieW pracy przedstawiono rzadką postać nabytej niedokrwistości aplastycznej (AA), anemię aplastyczną związaną z uszkodzeniem wątroby (hepatitis-associated aplastic anemia – HAAA). Choroba dotyczy młodych mężczyzn bez wcześniejszego wywiadu chorób przewlekłych. Najczęściej stwierdza się zapalenie wątroby przebiegające ze wzrostem enzymów wątrobowych, zazwyczaj również z hiperbilirubinemią. Po około 2-3 miesiącach od objawów zapalenia wątroby u chorych rozwija się niedokrwistość aplastyczna. U większości z tych pacjentów badania wirusologiczne są negatywne. Podejrzewa się zakażenie wirusami zapalenia wątroby trudnymi do identyfikacji, innymi niż wirusy A, B, C czy G. Efekty leczenia immunosupresyjnego oraz transplantacji komórek macierzystych hematopoezy są porównywalne w HAAA, jak w AA bez cech uszkodzenia wątroby.
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