The β2-adrenoreceptor gene promoter polymorphisms may modulate β2-agonist- and glucocorticoid-induced IgE synthesis

Chałubiński, Maciej; Grzegorczyk, Janina; Grzelak, Anna; Jarzębska, Marzanna; Kowalski, Marcin

doi:10.1016/j.aller.2013.07.002

Cited by 2 publications

(1 citation statement)

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“…This opens a crucial new viewpoint on genetics where environmental stimuli are related to selected genotypes to explain the phenotype. Another example is the β2-adrenoreceptor gene promoter polymorphism that determines modulation of IgE production as a response to xenobiotics (β2-agonists and glucocorticoids) ( 179 ).…”

Section: What Do We Know About the Genetic Basis Of Ige-mediated Automentioning

confidence: 99%

Immunoglobulin E-Mediated Autoimmunity

et al. 2018

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The study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, which may be termed autoallergy, is in its infancy. It is now recognized that systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, both spontaneous and inducible, are most likely to be mediated, at least in part, by IgE autoantibodies. The situation in other conditions, such as autoimmune uveitis, rheumatoid arthritis, hyperthyroid Graves’ disease, autoimmune pancreatitis, and even asthma, is far less clear but evidence for autoallergy is accumulating. To be certain of an autoallergic mechanism, it is necessary to identify both IgE autoantibodies and their targets as has been done with the transmembrane protein BP180 and the intracellular protein BP230 in BP and IL-24 in chronic spontaneous urticaria. Also, IgE-targeted therapies, such as anti-IgE, must have been shown to be of benefit to patients as has been done with both of these conditions. This comprehensive review of the literature on IgE-mediated autoallergy focuses on three related questions. What do we know about the prevalence of IgE autoantibodies and their targets in different diseases? What do we know about the relevance of IgE autoantibodies in different diseases? What do we know about the cellular and molecular effects of IgE autoantibodies? In addition to providing answers to these questions, based on a broad review of the literature, we outline the current gaps of knowledge in our understanding of IgE autoantibodies and describe approaches to address them.

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Section: What Do We Know About the Genetic Basis Of Ige-mediated Automentioning

confidence: 99%