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Introduction The absence of microbial growth and resistance to oxidative deterioration in fruits of Musa × paradisiaca L. (bananas) is an indication of the presence of antimicrobial and antioxidant metabolites. Objective In order to investigate the secondary metabolomic spectrum as well as the active antimicrobial and antioxidants present in essential oils (EOs) from fruits of different geographical areas of M. × paradisiaca, gas chromatography‐mass spectroscopy (GC‐MS) principal component data correlation analysis is complemented with antimicrobial assays and phytochemical and bioautographic antioxidant fingerprints with thin layer chromatography (TLC). Methodology An EO was obtained by steam distillation and subjected to GC‐MS and TLC for metabolomic profiling from fruit pulp. The antimicrobial potential was tested in both Escherichia coli as a gram negative and Bacillus subtilis as a gram positive microbe. Potential antioxidant metabolites were identified through TLC‐bioautography and GC‐MS analysis of active zones. Results A maximum of 0.56% v/w EO was isolated from fruit pulps of M. × paradisiaca. Minimum inhibitory concentrations (MICs) against B. subtillis and E. coli were 0.25 and 0.35 μg/mL, respectively. Thus, 56 metabolites were identified through GC‐MS. The major abundant antimicrobial metabolites found in EOs are α‐thujene, γ‐terpinene, α‐ and β‐pinene, sabinene, β‐myrcene, limonene, α‐capaene, caryophyllene and (Z,E)‐α farnesene. Aceteugenol, palmitic acid, stearic acid, palmitin, and stearin were identified as antioxidant metabolites. Principal component analysis of metabolite data reveals correlations and a clear separation based on metabolites obtained from various areas. Conclusion The data generated using metabolic profiling and cluster analysis helped to identify antimicrobial and antioxidant compounds in M. × paradisiaca.

Friction and wear behavior of silicon carbide based aluminum metal matrix composite and aluminum matrix alloy have been studied for sliding speeds of 3.14 m/s and 3.77 m/s and load range from 10 N to 30 N under dry and lubricated environment, respectively. The experiments were performed on pin on disk tribometer (Make: DUCOM). The composite was fabricated by stir casting process and has several challenges like inferior bonds and interfacial reaction products which will deteriorate the mechanical and tribological properties. Therefore, addition of reactive metal like magnesium (Mg) should be done which will lead to reduced solidification shrinkage, lower tendency towards hot tearing, and faster process cycles. Results have revealed that the developed composites have lower coefficient of friction and wear rates when compared with aluminum matrix alloy under dry and lubricated environment. Experimental results show that under dry condition coefficient of friction of both the matrix alloy and the composite decreases with increase in load, whereas it increases with increase in sliding speeds; on the other hand wear rates of both aluminum matrix alloy and the composites increase with increase in load as well as with sliding speeds. FESEM of worn surfaces are also used to understand the wear mechanisms.

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A series of imines 5-amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamide derivatives were synthesized from various aromatic aldehydes and substituted with benzoyl acetazolamides under different reaction conditions and were evaluated for their antioxidant and free radical scavenging, antimitotic activity by Allium cepa meristem root model and cytotoxicity activity against HEK 293 (human epidermal kidney cell line), BT474 (breast cancer cell line) and NCI-H226 (lung cancer cell line) by MTT assay. Some of the synthesized compounds showed moderately potent cytotoxicity compared to indisulam. Graphical abstractA series of imines 5-amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamide derivatives (9a–j); 5-amino-1,3,4-thiadiazol-2-[N-(substituted benzoyl)]sulphonamide (4a–g); 5-(4-acetamido phenyl sulphonamido)-1,3,4-thiadiazol-2-[N-(substituted benzoyl)]sulphonamide (6a–g); and 5-(4-amino phenyl sulphonamido)-1,3,4-thiadiazol-2-[N-(substituted benzoyl)]sulphonamide (7a–g) were synthesized from acetazolamide and were investigated for the in vitro anticancer by MTT assay, free radical scavenging and antimitotic activity by Allium cepa root meristem model. Experimental observations indicate that synthesized compounds were moderately potent anticancer agents.

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Tribological properties of silicon carbide-based aluminum metal matrix composite and aluminum matrix alloy have been studied for various sliding speeds of 3.14 and 3.77 m/s and load range from 10 to 30 N under dry, lubricated, and inert gas (argon) environment. Pin-on-disk tribometer were used for experiments. The composite was fabricated by stir casting route by using aluminum 7075 alloy as the matrix and 10% by weight silicon carbide as reinforced material. Results have revealed that the value of coefficient of friction is found to be maximum in case of inert condition in matrix alloy at sliding speed 3.77 m/s and minimum in case of lubricated condition in composite at sliding speed 3.14 m/s. The wear rate is least for both the alloy and the composite under lubricated condition compared with dry and inert condition. Wear rate increases with the normal load and sliding speed and it is maximum in inert condition of matrix alloy at 30 N. Uniform distribution of silicon carbide in aluminum matrix alloy reduces the values of coefficient of friction and wear rate for composites compared to aluminum matrix alloy under dry, lubricated, and inert condition which increases the life of the composites for longer duration. Silicon carbide significantly improves the strength the aluminum matrix alloy in dry, lubricated, and inert condition and acts as load-bearing members.

A QSAR study was performed on sulphonamide-1,3,4- The compounds, ,3,4-thiadiazol-2-(N-benzoyl) sulphonamide (9a) and 5-(4-amino) benzenesulphonamido-1,3,4-thiadiazol-2-sulphonamide (10a)