Tempe is a fermented soy bean product originally made by Central Javanese people through fermentation with Rhizopus species. Although there is evidence of earlier fermentation of soy, tempe had appeared in the Central Javanese food pattern in the 1700s. Through its extensive use in main meals and snacks, it has led to people in the Jakarta prectinct having the highest known soy intake in the world and accordingly of the isoflavones contained. This provides an unique opportunity to consider the health effects of tempe (and soy), both beneficial and potentially toxic. Apparent health benefits are bowel health, protection against cardiovascular disease, certain cancers (e.g. breast and prostate) and menopausal health (including bone health). The long use of tempe at all stages of life, without recognised adverse effects, suggests it is relatively safe at the levels of intake seen in Central Java. However, further research on soy, both fermented and non-fermented, in Central Java should yield more insight into the mechanisms of action and the safe ranges of intake.
Objective: This study aimed to evaluate the antidiabetic and antidepressant effects of banana peel flakes in streptozotocin-induced diabetic rats.
Methods: Twenty-five male Wistar rats were classified into five groups with different treatments. Groups I to IV were diabetic rats model groups that consumed only standard diet, standard diet containing 5%, 10%, and 20% of banana peel flakes, respectively. While group V was a healthy control group fed a standard diet. Immunohistochemistry staining was measured to examine serotonin expression in the colon and pancreas.
Results: The diabetic rats treated with 20% banana peel flakes had a lower blood glucose concentration (p<0.05) compared with diabetic control and showed a shorter duration of immobility time (p<0.05) than the healthy control. Additionally, compared with diabetic control, the diabetic rats treated with 5% banana peel flakes showed higher serotonin expression (p<0.05) in the colon. In contrast, serotonin expression in the pancreas did not show any significant difference (p>0.05).
Conclusion: The present study disclosed that the banana peel flakes provided an antidepressant effect in the diabetic rats model, which might occur through the mechanism of controlling blood glucose concentration.
A B S T R A C TA positive energy imbalance results in overweight and obesity. Overweight and obesity are the major risk factors for many diseases, including diabetes, cardiovascular diseases, and mental health. Animal studies suggested that serotonin involves in food intake control. The Banana peel is a potential natural source of serotonin precursor; furthermore, it may influence food intake. This study aimed to determine the effect of banana peel extract on food intake and body weight gain in male Wistar rats. Twenty-four male Wistar rats (8-10 weeks old), were divided into four groups for feeding treatment. All four group were; the control group (C), the banana peel extract dosage of 4 g/kg BW group (T1), the banana peel extract dosage of 8 g/kg BW (T2), and the banana peel extract dosage of 16 g/kg BW (T3). The food intakes were measured daily, while rats body weights were recorded at the beginning and the end of the three days experimental periods. The study found the rats in the T1 group (8.80 ± 2.63) showed no significant difference in food intake compared to C group (10.68 ± 1.89), T2 group (6.65 ± 3.12), and T3 group (5.42 ± 1.59). Rats in the T2 group (p = 0.038) and T3 group (p = 0.005) showed lower food intake significantly compared to control group. After three days of treatment, the T3 group showed a significant decrease in body weight compared to control group (p = 0.008). This study concluded, the administration of banana peel extract dosage of 8 g/kg BW and 16 g/kg BW suppressed food intake, while the dosage of 16 g/kg BW reduced the body weight in male Wistar rats.KEY WORDS: food intake, banana peel, Wistar rat Penulis korespondensi: WIWIEK FATCHUROHMAH |
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