Effects of Physical Exercise on Indicators of Inflammation Risk of the Gaster in a Male Wistar Rat Aging Model Created with D-galactose Induction

Effect of High-Calorie Diet and Moderate-Intensity Physical Exercise on Gastric Histopathological Features of Mice

“…A study conducted in 2018 revealed a reduced risk of gastric inflammation in Wistar rats that were given with mild to moderate-intensity physical exercise with a duration of 40 minutes, four times per week for four weeks. However, in that study, the moderate-intensity physical exercise was carried out using treadmill, which may have lead to different results from this present study (Murwaningsih et al 2018). Previous studies have indicated that swimming as a type of physical exercise offers greater advantages compared to other techniques, such as using a treadmill.…”

“…It can lower oxidative stress through several mechanisms, for instance, improving enzyme activity and DNA repair, reducing DNA binding to ROSsensitive transcription factors (such as NF-κB), and increasing the activity of cell enzymatic antioxidants, such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) (Berawi and Agverianti 2017). Previous studies have shown that moderate-intensity physical exercise reduces the risk of gastric inflammation and increases antioxidant status in experimental animals (Stone et al 2015;Murwaningsih et al 2018). However, the effects of high-calorie diet and moderate-intensity physical exercise on gastric histopathological features are still unclear.…”