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The present investigation was undertaken to study the effect of Moringa oleifera Lam. on haematological and histopathological changes in the liver and kidney in wistar rats, induced with sodium fluoride toxicity and vitamin C. Thirty six female wistar rats were divided into six groups (T 1, T 2, T 3, T 4, T 5 and T 6 ), each comprising of six rats. T 1 served as negative control which received normal saline only. T 2 served as positive control, received sodium fluoride @ 20 mg/kg b.wt. only, T 3 received fluoride @ 20 mg/kg b.wt along with ascorbic acid @ 200 mg/kg b.wt and treatment was given to T 4 , T 5 and T 6 with different doses, viz., 250, 500 and 750 mg/kg b.wt of aqueous extract of M. oleifera, respectively along with sodium fluoride. The blood was collected after 28 days for serum haematological parameters study and then all the rats were sacrificed for histopathological studies. On total RBC count, though values were noted in increasing direction from graph but statistically analysed were found non significant. The haemoglobin, WBC and PCV were shown to be restored significantly on induced toxicity rats. Histopathological alterations in T 3 , T 4 , T 5 and T 6 were observed milder degree as compared to T 2 . The alterations in three (T 4 , T 5 and T 6 ) groups when compared to the fluoride administered group showed high degree of protective effect treatment on kidney, by using aqueous extracts shows the toxic changes.

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