Summary Background Skincare cosmeceutical products have been shown to address intrinsic and extrinsic skin aging. Radiofrequency (RF) with microneedling is effective and safe in improving skin laxity and texture. Pairing skincare cosmeceutical products pre‐ and post‐procedure is beneficial as it enhances patient results, patient results, patient experience, and reduces patient downtime. Objective To evaluate the tolerability, safety, and efficacy of a multi‐ingredient anti‐aging facial moisturizer when applied pre‐ and post‐procedure consisting of a single RF microneedling treatment. Method Fifteen female patients, aged 37‐60, Fitzpatrick skin types I‐IV, with mild‐to‐moderate wrinkles were included in the study. Patients applied a multi‐ingredient anti‐aging facial moisturizer twice a day (morning and night) two weeks prior to RF microneedling and four weeks post‐RF microneedling (twice a day). At each time point, investigator objective assessment, self‐assessments, and clinical photography were taken. Result There were no adverse events as evaluated by the investigator. For this combined treatment and procedure patient scored comfort as the highest for satisfaction. Tolerability parameters erythema and edema were reported after RF microneedling treatment and were significant compared to the pre‐procedure timepoint. Eighty percent of patients showed an improvement in Glogau Wrinkle Scale, but improvement was not statistically significant between baseline and end of study. Improvements in all skin attributes (radiance, tone, smoothness, texture, redness, dryness, and overall appearance) were statistically significant at the end of the study. Self‐perceived skin attribute improvements included overall improvement, brightness, texture, pigmentation, redness, and tightness. The combination of the anti‐aging facial moisturizer and RF microneedling was recommended by the patients in this study. Conclusion This clinical study positively supports the hypothesis that combining the multi‐ingredient anti‐aging facial moisturizer pre‐ and post‐RF microneedling was safe and tolerable for the patients.

Aims:To assess the effect of a 28-day skincare regimen in healthy female subjects on the facial skin microbiome composition and to determine whether the skincare regimen including a gentle cleansing lotion, a multi-functional anti-aging moisturizer formulated with prebiotics and postbiotics at skin neutral pH, and bland sunscreen pushed the microbiome to a healthier state and improved skin aging measured by self-assessment and clinical photography. Methods and Results:The study protocol was in accordance with the EU Scientific Committee on Consumer Safety (SCCS) guidance and met all international standards. In all, 25 female subjects between 35 and 65 years old with Fitzpatrick skin types I-VI, moderate crow's feet wrinkles and global face photodamage were enrolled. After 28 days, the skincare regimen improved microbial facial diversity and shifted the microbiota composition when compared to baseline.Conclusions: After 28 days, the skincare regimen treatment shifted the distribution of the facial skin microbiome, positively influencing the skin microbiome diversity and balance, to promote long-term skin health and protect from further skin aging.Significance and Impact of the Study: These results suggest that incorporating prebiotics and postbiotics into a skincare regimen may have a positive impact on the facial skin microbiome in healthy women.

Background Melasma is a chronic pigmentary condition that can have significant negative effects on quality of life. Vitamin C can be effective in the treatment melasma, but its delivery often proves to be challenging due to instability of the drug and subsequent cutaneous irritation at higher concentrations. Aim In this prospective, open‐label, evaluator‐blinded study, we aimed to assess the efficacy and tolerability of twice‐daily application of a novel, highly potent, non‐irritating 30% tetrahexyldecyl (THD) ascorbate serum in combination with 100% mineral‐based sunscreen in the treatment of melasma during the summer months. Patients/Methods Ten female subjects of ages ranging from 18 to 60 years underwent twice‐daily application of 30% THD ascorbate serum in combination with an anti‐aging 100% mineral tinted broad‐spectrum protection SPF 45 sunscreen moisturizer for 12 weeks during the summer months (July to September). Two blinded evaluators scored baseline and post‐treatment photographs using the Griffiths’ 10‐point scale and global aesthetic improvement scale. Results All subjects showed an improvement in hyperpigmentation with an average improvement of 33.7%. Seventy percent of subjects showed an improvement in skin tone evenness (redness), and among those subjects, the average improvement was 33.3%. The median global aesthetic improvement score was 2.0 (very much improved). Conclusion Our study demonstrated efficacy and safety in treating the pigmentary as well as vascular components of melasma with a novel 30% THD ascorbate serum and a purely mineral‐based tinted moisturizing sunscreen.

Background Skin aging of upper arm, induced by intrinsic and extrinsic factors, often results in loss of contour, elasticity and firmness, and increase in laxity, crepiness, roughness and photodamage. A topical body firming moisturizer (TBFM) was developed to target all aspects of aged body skin. Objective The aim of this study was to evaluate the efficacy and tolerability of the TBFM for upper arm firming and rejuvenation. Methods Forty female subjects, 40-60 years old, Fitzpatrick skin type II-V, with mild to moderate laxity, crepiness, and photodamage on the upper arms were recruited into the study, 10 of whom were selected for biopsy analysis. Subjects were randomized to apply the TBFM and placebo moisturizer on the assigned arms twice daily for 12 weeks. At each visit, efficacy and tolerability evaluation, self-assessment, and standardized clinical photography were taken. Ultrasound measurements were performed at baseline, week 8 and week 12. Results Results from the efficacy evaluation by the clinical grader and bio-instrumentation analysis showed the TBFM improved all skin parameters of the aged upper arm while outperforming the placebo moisturizer after 12 weeks. Clinical photography showed the test product was able to tone and firm the skin. The TBFM was well-tolerated and well-perceived by the subjects. Ultrasound images illustrated an improvement in skin density and skin structure at week 12. Conclusion This clinical trial positively supports the hypothesis that the TBFM was effective and tolerable in improving crepey, lax, and photodamaged skin of the upper arms after 12 weeks of treatment twice daily.

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