A multi-functional anti-aging moisturizer maintains a diverse and balanced facial skin microbiome

Abstract

Aims:To assess the effect of a 28-day skincare regimen in healthy female subjects on the facial skin microbiome composition and to determine whether the skincare regimen including a gentle cleansing lotion, a multi-functional anti-aging moisturizer formulated with prebiotics and postbiotics at skin neutral pH, and bland sunscreen pushed the microbiome to a healthier state and improved skin aging measured by self-assessment and clinical photography. Methods and Results:The study protocol was in accordance with the EU Scientific Committee on Consumer Safety (SCCS) guidance and met all international standards. In all, 25 female subjects between 35 and 65 years old with Fitzpatrick skin types I-VI, moderate crow's feet wrinkles and global face photodamage were enrolled. After 28 days, the skincare regimen improved microbial facial diversity and shifted the microbiota composition when compared to baseline.Conclusions: After 28 days, the skincare regimen treatment shifted the distribution of the facial skin microbiome, positively influencing the skin microbiome diversity and balance, to promote long-term skin health and protect from further skin aging.Significance and Impact of the Study: These results suggest that incorporating prebiotics and postbiotics into a skincare regimen may have a positive impact on the facial skin microbiome in healthy women.

A narrative review of the impact of ultraviolet radiation and sunscreen on the skin microbiome

“…UV filters, such as uncoated and coated ZnO and TiO 2 nanoparticles have antimicrobial properties; however, few studies have directly investigated the effect of sunscreen on the cutaneous microbiome 10,12,14,15 . The composition of sunscreen emulsions is also an important consideration given its ability to change the microenvironment of the skin and the potential for compounds to persist on the skin for weeks 11,13,27 . There is limited direct evidence on the effects of UVR on the skin microbiome, the effects of sunscreen on the microbiome, and how the microbiome can protect the skin from UVR.…”

“…10,12,14,15 The composition of sunscreen emulsions is also an important consideration given its ability to change the microenvironment of the skin and the potential for compounds to persist on the skin for weeks. 11,13,27 There is limited direct evidence on the effects of UVR on the skin microbiome, the effects of sunscreen on the microbiome, and how the microbiome can protect the skin from UVR. Differentiating between the effects of UVR and other environmental factors such as diet, clothing, and lifestyle on the microbiome is challenging.…”

“…27 Theoretically, an emulsion that has a skin neutral pH, prebiotics, and post-biotics may be beneficial in maintaining skin microbial diversity. 11 Many sunscreens contain similar preservatives and compounds found in other personal hygiene products and cosmetics. This indicates that application of certain sunscreen products could cause lasting alterations on the skin microenvironment and microbiome.…”

“…Compounds in cosmetic products, such as sugars, proteins, and nutrients have the potential to alter the microenvironment and microbiome of the skin 27 . Theoretically, an emulsion that has a skin neutral pH, prebiotics, and post‐biotics may be beneficial in maintaining skin microbial diversity 11 . Many sunscreens contain similar preservatives and compounds found in other personal hygiene products and cosmetics.…”

“…However, the impact of sunscreens on the microbiome is less clear. Sunscreen products typically contain a large variety of ingredients, such as UV filters, antioxidants, and preservatives 10,11 . There is also significant variability in the ingredients used between different products.…”