An open‐label, single‐site study to evaluate the tolerability, safety, and efficacy of using a novel facial moisturizer for preparation and accelerated healing pre and post a single full‐face radiofrequency microneedling treatment

Abstract

Summary Background Skincare cosmeceutical products have been shown to address intrinsic and extrinsic skin aging. Radiofrequency (RF) with microneedling is effective and safe in improving skin laxity and texture. Pairing skincare cosmeceutical products pre‐ and post‐procedure is beneficial as it enhances patient results, patient results, patient experience, and reduces patient downtime. Objective To evaluate the tolerability, safety, and efficacy of a multi‐ingredient anti‐aging facial moisturizer when applied pre‐ and post‐procedure consisting of a single RF microneedling treatment. Method Fifteen female patients, aged 37‐60, Fitzpatrick skin types I‐IV, with mild‐to‐moderate wrinkles were included in the study. Patients applied a multi‐ingredient anti‐aging facial moisturizer twice a day (morning and night) two weeks prior to RF microneedling and four weeks post‐RF microneedling (twice a day). At each time point, investigator objective assessment, self‐assessments, and clinical photography were taken. Result There were no adverse events as evaluated by the investigator. For this combined treatment and procedure patient scored comfort as the highest for satisfaction. Tolerability parameters erythema and edema were reported after RF microneedling treatment and were significant compared to the pre‐procedure timepoint. Eighty percent of patients showed an improvement in Glogau Wrinkle Scale, but improvement was not statistically significant between baseline and end of study. Improvements in all skin attributes (radiance, tone, smoothness, texture, redness, dryness, and overall appearance) were statistically significant at the end of the study. Self‐perceived skin attribute improvements included overall improvement, brightness, texture, pigmentation, redness, and tightness. The combination of the anti‐aging facial moisturizer and RF microneedling was recommended by the patients in this study. Conclusion This clinical study positively supports the hypothesis that combining the multi‐ingredient anti‐aging facial moisturizer pre‐ and post‐RF microneedling was safe and tolerable for the patients.

Pre‐/postprocedure measures for minimally invasive, nonenergy aesthetic treatments: A survey

“…For example, because abrasion produces slight impairments of the skin barrier, 19 topical formulations used in conjunction with the procedure may reduce irritation and downtime. One previous study demonstrated the safety, tolerability and efficacy of a multi‐ingredient anti‐aging facial moisturizer, 20 when used pre‐ and postmicroneedling; while other investigators have shown that topical tri‐ and hexapeptide‐containing products hasten healing and complement aesthetic outcomes of microneedling 18 . Furthermore, by decreasing the severity and duration of the inflammatory period, the risks of causing a flare‐up of any pre‐existing inflammatory disease (eg, psoriasis, eczema, atopic, or contact dermatitis) may be reduced.…”

A topical regimen improves skin healing and aesthetic outcomes when combined with a radiofrequency microneedling procedure

“…The use of microneedling has demonstrated efficacy for treating dyschromia, atrophic scars, and for rejuvenating photodamaged skin on the face and décolleté . Although microneedling has an excellent safety profile, treatment‐related adverse events may include at least minor pain or discomfort, erythema, and edema . Based on the promising results of topical products containing tri‐ and hexapeptides formulated using proprietary TriHex Technology ® , the products used in the present study were developed to reduce the severity of treatment‐related adverse events and improving aesthetic outcomes following RF microneedling of the neck.…”

Radiofrequency microneedling for acne, acne scars, and more

“…Another study with an RFM device included 45 patients at three clinics in the United States. All of the patients experienced a 75% to 80% improvement in hyperhidrosis after three treatments with multiple passes with depths of 2.5 to 3.5 mm 10 …”

“…Another study by the same group evaluated an antiaging multi‐ingredient lotion used twice daily for 2 weeks prior and 4 weeks post one RFM treatment in 15 patients. This regimen led to significant improvement in skin radiance, texture, tone, smoothness, redness, and overall appearance 10 . Another option is to apply platelet‐rich plasma after an RFM treatment.…”