A Randomized, Double-Blind, Split-Body, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Tolerability of a Topical Body Firming Moisturizer for Upper Arm Rejuvenation

Abstract

Background Skin aging of upper arm, induced by intrinsic and extrinsic factors, often results in loss of contour, elasticity and firmness, and increase in laxity, crepiness, roughness and photodamage. A topical body firming moisturizer (TBFM) was developed to target all aspects of aged body skin. Objective The aim of this study was to evaluate the efficacy and tolerability of the TBFM for upper arm firming and rejuvenation. Methods Forty female subjects, 40-60 years old, Fitzpatrick skin type II-V, with mild to moderate laxity, crepiness, and photodamage on the upper arms were recruited into the study, 10 of whom were selected for biopsy analysis. Subjects were randomized to apply the TBFM and placebo moisturizer on the assigned arms twice daily for 12 weeks. At each visit, efficacy and tolerability evaluation, self-assessment, and standardized clinical photography were taken. Ultrasound measurements were performed at baseline, week 8 and week 12. Results Results from the efficacy evaluation by the clinical grader and bio-instrumentation analysis showed the TBFM improved all skin parameters of the aged upper arm while outperforming the placebo moisturizer after 12 weeks. Clinical photography showed the test product was able to tone and firm the skin. The TBFM was well-tolerated and well-perceived by the subjects. Ultrasound images illustrated an improvement in skin density and skin structure at week 12. Conclusion This clinical trial positively supports the hypothesis that the TBFM was effective and tolerable in improving crepey, lax, and photodamaged skin of the upper arms after 12 weeks of treatment twice daily.

A Rejuvenating treatment targeting “tech neck” lines and wrinkles in Chinese women: A prospective, open‐label, single‐center study

“…These results may be due to improved skin density and triglyceride breakdown in the subcutaneous adipose tissue. 15,16 Across all subjects, there was an overall trend of increased dermal density observed in ultrasound measurements and images between baseline and D84.…”

Improving Body Skin Quality: Evidence-Based Development of Topical Treatment and Survey of Current Options

“…Remove fatty acids, cellular waste, and excess fluid 39 At 8 and 12 weeks, the proportion of patients with specific improvements impacting skin quality, as judged by a blinded clinical grader, was significantly greater for BodiFirm than for placebo (P≤0.05). At 12 weeks, BodiFirm treatment was associated with improvements in skin crepiness in 97% of subjects, underarm laxity in 83% of subjects, and photodamage in 83% of subjects; and BodiFirm also demonstrated significantly greater response rates versus baseline for skin roughness, firmness (visual), skin tone evenness (lack of red areas), and hyperpigmentation.…”

“…However, only the percentage of responders (not the degree of improvement) was directly compared between treatments. 39 In a randomized, double-blind, split-body pilot study, TransFORM Body Treatment with TriHex Technology (TBT; Alastin Skincare, Inc., Carlsbad, CA) was compared with a bland moisturizer in women (N=11; age range, 25-65 years) following cryolipolysis (CoolSculpting System; Allergan Aesthetics, an AbbVie Company, Irvine, CA) for bilateral reduction of upper arm adiposity. 8 Subjects applied each treatment to opposing arms (treatment assignment was randomized) twice daily for 24 weeks post-procedure.…”

Emerging Evidence for the Effectiveness of Profhilo® Figura Body Cream in Enhancing Skin Hydration, Elasticity, and Firmness

“…The dermal skin layer, consisting of complex extracellular matrix proteins and collagen fibers, provides skin strength and elasticity [1]. Both intrinsic factors (influenced by genetics) and extrinsic components (chronic exposure to environmental aggressors, such as ultraviolet radiation) induce skin aging [2]. Intrinsically aged skin is characteristically thin and dry, with increased laxity and a crepe-like texture, while extrinsically aged skin is typically thick, coarse, leathery, and has uneven pigmentation [2].…”

“…Both intrinsic factors (influenced by genetics) and extrinsic components (chronic exposure to environmental aggressors, such as ultraviolet radiation) induce skin aging [2]. Intrinsically aged skin is characteristically thin and dry, with increased laxity and a crepe-like texture, while extrinsically aged skin is typically thick, coarse, leathery, and has uneven pigmentation [2]. Overall, the aging process in the body generates an undesirable skin appearance, including laxity and a crepe-like appearance, as well as increased localized fat Volume 09; Issue 02 Ann Case Rep, an open access journal ISSN: 2574-7754 accumulation [2].…”