Clinical Study to Evaluate the Efficacy and Tolerability of Cosmeceuticals Targeting the Dermal-Epidermal Junction

Addae, Ajoa; Zahr, Alisar S.; Jiang, Lily I.; Desai, Seemal R.; Kononov, Tatiana

doi:10.36849/jdd.6355

Cited by 3 publications

(6 citation statements)

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“…After 12 weeks of twice daily application of the MFM, 10.3% average improvement was noted in 85.7% of subjects in tactile firmness of the facial skin (*** p < 0.001), 12.6% average improvement in overall photodamage (*** p < 0.001) and 25.9% average improvement in full face radiance (*** p < 0.001). Additionally, skin pH measurements remained within skin neutral pH of 4.5–5.5 during the 12 weeks (Addae et al, 2021). The current study demonstrated that a topical skin care regimen consisting of twice daily application of a gentle cleansing lotion and MFM formulated at a skin‐neutral pH in addition to once daily application of a sunscreen over 28 days had a positive impact on the skin microbiome across 25 female subjects.…”

Section: Discussionmentioning

confidence: 99%

“…A novel multi‐ingredient anti‐aging facial moisturizer (MFM) was exclusively formulated at skin neutral pH (4.5–5.5) to treat global aging facial skin by targeting and improving the DEJ (Addae et al, 2021). The MFM contains unique ingredients including Astragalus membranaceus root extract, Ursolic acid and Tetrahexyldecyl (THD) ascorbate to promote wound healing and inhibit UVA‐induced photoaging (Sevimli‐Gür et al, 2011; Soo Lee et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…The enhanced MFM formulated with the aforementioned ingredients creates a robust, multi‐targeted anti‐aging moisturizer with the ability to re‐establish the DEJ, and balance and diversify the skin microbiome (Addae et al, 2021). In this current clinical study, microbial content, consumer perception, clinical photography and subject tolerability were all analysed to assess the impact of the enhanced MFM on the skin microbiome in 25 female subjects with twice daily application for 28 days in protecting and restoring the skin from the detrimental changes induced by intrinsic and extrinsic aging.…”

Section: Introductionmentioning

confidence: 99%

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A multi-functional anti-aging moisturizer maintains a diverse and balanced facial skin microbiome

Iglesia¹,

Kononov²,

Zahr³

2022

Journal of Applied Microbiology

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Aims:To assess the effect of a 28-day skincare regimen in healthy female subjects on the facial skin microbiome composition and to determine whether the skincare regimen including a gentle cleansing lotion, a multi-functional anti-aging moisturizer formulated with prebiotics and postbiotics at skin neutral pH, and bland sunscreen pushed the microbiome to a healthier state and improved skin aging measured by self-assessment and clinical photography. Methods and Results:The study protocol was in accordance with the EU Scientific Committee on Consumer Safety (SCCS) guidance and met all international standards. In all, 25 female subjects between 35 and 65 years old with Fitzpatrick skin types I-VI, moderate crow's feet wrinkles and global face photodamage were enrolled. After 28 days, the skincare regimen improved microbial facial diversity and shifted the microbiota composition when compared to baseline.Conclusions: After 28 days, the skincare regimen treatment shifted the distribution of the facial skin microbiome, positively influencing the skin microbiome diversity and balance, to promote long-term skin health and protect from further skin aging.Significance and Impact of the Study: These results suggest that incorporating prebiotics and postbiotics into a skincare regimen may have a positive impact on the facial skin microbiome in healthy women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A multi-functional anti-aging moisturizer maintains a diverse and balanced facial skin microbiome

Iglesia¹,

Kononov²,

Zahr³

2022

Journal of Applied Microbiology

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“…Additionally, the AADS was paired with a multi-ingredient anti-aging facial moisturizer (AAFM) to evaluate potential boosting effects. 14 The objective of this study was to evaluate the efficacy and tolerability for use of the AADS as a stand-alone short-term treatment as well as combined with an AAFM in photodamaged and fatigued skin.…”

Section: Introductionmentioning

confidence: 99%

“…In conjunction, a prospective, randomized, double‐blinded, controlled short‐term in‐vivo case study was conducted with the hypothesis that the AADS would effectively treat women with moderate fatigued skin and overall photodamaged skin when used twice daily over the course of 7‐days. Additionally, the AADS was paired with a multi‐ingredient anti‐aging facial moisturizer (AAFM) to evaluate potential boosting effects 14 . The objective of this study was to evaluate the efficacy and tolerability for use of the AADS as a stand‐alone short‐term treatment as well as combined with an AAFM in photodamaged and fatigued skin.…”

Section: Introductionmentioning

confidence: 99%

A case study investigating the short‐term efficacy and tolerability of a daily serum composed from a unique sunflower sprout extract

Barua

Jiang

Kononov³

et al. 2022

J of Cosmetic Dermatology

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Background Fatigued skin, defined as dehydrated skin with lack of visual facial firmness and dull appearance, can be attributed to intrinsic and extrinsic factors of aging. An anti‐aging daily serum (AADS) containing a unique sunflower sprout extract (SSE) was formulated to target fatigued and photodamaged skin. Aims Utilizing both preclinical and clinical testing models, the efficacy of the AADS was investigated to improve fatigued and photodamaged skin. Patients/Method Preclinical studies included in vitro analysis of adenosine triphosphate (ATP) production in fatigued dermal fibroblasts, inhibition of ultraviolet radiation A (UVA) induced advanced glycation end products (AGEs) in keratinocytes, and ex vivo gene expression after incubation with the SSE. An institutional review board (IRB)‐approved short‐term, 7‐day, clinical case study was conducted on 28 female subjects, Fitzpatrick skin type I–IV, aged 30–60 years with moderate overall photodamage and skin fatigue. This was a double‐blinded, randomized, controlled, single‐center case study testing the AADS alone and in combination with an anti‐aging facial moisturizer (AAFM). Results The SSE boosted intracellular ATP production in fatigued fibroblasts and reduced the formation of AGEs in keratinocytes. The SSE increased expression of genes related to epidermal keratinization and downregulated genes related to inflammation. Statistically significant improvement was found after 7 days of twice‐daily use of the AADS alone and in combination with the AAFM. Products were well tolerated and perceived by subjects. Conclusion Preclinical results combined with the clinical results strongly suggest that the AADS containing the SSE was tolerable and effective in targeting fatigued and photodamaged skin.

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Efficacy and Safety of Epidermidibacterium Keratini EPI-7 Derived Postbiotics in Skin Aging: A Prospective Clinical Study

Kim

Lee

Mun

et al. 2023

IJMS

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The present study investigated the effect of topical application of Epidermidibacterium Keratini (EPI-7) ferment filtrate, which is a postbiotic product of a novel actinobacteria, on skin aging, by performing a prospective randomized split-face clinical study on Asian woman participants. The investigators measured skin biophysical parameters, including skin barrier function, elasticity, and dermal density, and revealed that the application of the EPI-7 ferment filtrate-including test product resulted in significantly higher improvements in barrier function, skin elasticity, and dermal density compared to the placebo group. This study also investigated the influence of EPI-7 ferment filtrate on skin microbiome diversity to access its potential beneficial effects and safety. EPI-7 ferment filtrate increased the abundance of commensal microbes belonging to Cutibacterium, Staphylococcus, Corynebacterium, Streptococcus, Lawsonella, Clostridium, Rothia, Lactobacillus, and Prevotella. The abundance of Cutibacterium was significantly increased along with significant changes in Clostridium and Prevotella abundance. Therefore, EPI-7 postbiotics, which contain the metabolite called orotic acid, ameliorate the skin microbiota linked with the aging phenotype of the skin. This study provides preliminary evidence that postbiotic therapy may affect the signs of skin aging and microbial diversity. To confirm the positive effect of EPI-7 postbiotics and microbial interaction, additional clinical investigations and functional analyses are required.

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Clinical Study to Evaluate the Efficacy and Tolerability of Cosmeceuticals Targeting the Dermal-Epidermal Junction

Cited by 3 publications

References 0 publications

A multi-functional anti-aging moisturizer maintains a diverse and balanced facial skin microbiome

A multi-functional anti-aging moisturizer maintains a diverse and balanced facial skin microbiome

A case study investigating the short‐term efficacy and tolerability of a daily serum composed from a unique sunflower sprout extract

Efficacy and Safety of Epidermidibacterium Keratini EPI-7 Derived Postbiotics in Skin Aging: A Prospective Clinical Study

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