Hydrogels are macromolecular networks able to absorb and release water solutions in a reversible manner, in response to specific environmental stimuli. Such stimuli-sensitive behaviour makes hydrogels appealing for the design of ‘smart’ devices, applicable in a variety of technological fields. In particular, in cases where either ecological or biocompatibility issues are concerned, the biodegradability of the hydrogel network, together with the control of the degradation rate, may provide additional value to the developed device. This review surveys the design and the applications of cellulose-based hydrogels, which are extensively investigated due to the large availability of cellulose in nature, the intrinsic degradability of cellulose and the smart behaviour displayed by some cellulose derivatives.

This work is focused on the preparation of new environmentally friendly hydrogels derived from cellulose and hence originating from renewable resources and characterized by biodegradable properties. Two cellulose derivatives, sodium carboxymethylcellulose (CMCNa) and hydroxyethylcellulose (HEC), were used for superabsorbent hydrogel preparation. Citric acid (CA), a crosslinking agent able to overcome toxicity and costs associated with other crosslinking reagents, was selected in a heat activated reaction. Differential scanning calorimeter (DSC), fourier transform infrared spectroscopy (FTIR), and swelling measurements were performed during the reaction progress to investigate the CA reactivity with each of the polymers. Also, CMCNa/HEC polymer mixtures (3/1 w/ w) crosslinked with CA were investigated and compared with previous results. Finally, a possible reaction mechanism was proposed.

Wound closure represents a primary goal in the treatment of very deep and/or large wounds, for which the mortality rate is particularly high. However, the spontaneous healing of adult skin eventually results in the formation of epithelialized scar and scar contracture (repair), which might distort the tissues and cause lifelong deformities and disabilities. This clinical evidence suggests that wound closure attained by means of skin regeneration, instead of repair, should be the true goal of burn wound management. The traditional concept of temporary wound dressings, able to stimulate skin healing by repair, is thus being increasingly replaced by the idea of temporary scaffolds, or regenerative templates, able to promote healing by regeneration. As wound dressings, polymeric hydrogels provide an ideal moisture environment for healing while protecting the wound, with the additional advantage of being comfortable to the patient, due to their cooling effect and non-adhesiveness to the wound tissue. More importantly, recent advances in regenerative medicine demonstrate that bioactive hydrogels can be properly designed to induce at least partial skin regeneration in vivo. The aim of this review is to provide a concise insight on the key properties of hydrogels for skin healing and regeneration, particularly highlighting the emerging role of hydrogels as next generation skin substitutes for the treatment of full-thickness burns.

Superabsorbent hydrogels are a particular class of gels, obtained by chemical stabilization of hydrophilic polymers in a tridimensional network. Hydrogels have been widely proposed over the last 40 years for agricultural use with the aim to ameliorate water availability for plants, by increasing water holding properties of growing media (soils or soilless substrates). Most of the traditional hydrogels on the market are acrylate-based products, thus not biodegradable. Due to the increasing attention for environmental protection issues, biodegradable hydrogels arise lively interest for potential commercial application in agriculture. In this study, we evaluated a novel class of cellulose-based superabsorbent hydrogels, totally biodegradable and biocompatible, for agricultural use. The objectives of the tests carried out were: 1) to verify the ability of the hydrogel to modify the water retention properties of the growing media (soils and soilless substrates); 2) to study the effects on the growth of plants grown on media amended with the hydrogel. Water retention curve of a sandy soil amended with 0, 0.5, 1.0 and 2.0% (w/w) of hydrogel was determined using a Richard's pressure plate apparatus. The hydrogel modified the soil water retention properties. The soil moisture at field capacity increased with the highest hydrogel percentage up to 400% compared to the not amended soil, and at wilting point (-15 bar) was similar to that at field capacity of the not amended soil. When added to perlite, a low water holding capacity soilless substrate, 1 or 2% (w/w) of hydrogel increased the container capacity of 28 and 48%, respectively, with no decrease of air capacity. Tests revealed absence of phytotoxicity of the hydrogel, and cultivation trials on cucumber (on soil) and sweet basil (in soilless conditions) showed a general overall enhancement of plant growth and quality when hydrogel was added to growing media. The tested hydrogel showed to be suitable for potential use in agriculture. Its employment should be further evaluated under a cost-effective perspective.

The present work deals with the development of a biodegradable superabsorbent hydrogel, based on cellulose derivatives, for the optimization of water resources in agriculture, horticulture and, more in general, for instilling a wiser and savvier approach to water consumption. The sorption capability of the proposed hydrogel was firstly assessed, with specific regard to two variables that might play a key role in the soil environment, that is, ionic strength and pH. Moreover, a preliminary evaluation of the hydrogel potential as water reservoir in agriculture was performed by using the hydrogel in experimental greenhouses, for the cultivation of tomatoes. The soil-water retention curve, in the presence of different hydrogel amounts, was also analysed. The preliminary results showed that the material allowed an efficient storage and sustained release of water to the soil and the plant roots. Although further investigations should be performed to completely characterize the interaction between the hydrogel and the soil, such findings suggest that the envisaged use of the hydrogel on a large scale might have a revolutionary impact on the optimization of water resources management in agriculture.

The aim of this work was the implementation of a simple technique for the production of cylindrical collagen-based scaffolds with axially oriented pore channels. Matrices with this particular porous structure have the potential to improve the regeneration of peripheral nerves and spinal cord by physically supporting and guiding the growth of neural structures across the site of injury. The regenerative potential may be further enhanced when the collagen scaffold is used as a delivery vehicle for exogenous cells and growth factors. The scaffold manufacturing technique described here is based on unidirectional freezing of a collagen suspension and subsequent freeze-drying, which produces nearly axially oriented pores. The mean pore size is dependent on both the concentration of collagen in suspension and the temperature of freezing. Environmental scanning electron microscopy and light microscopy were used to assess qualitatively and quantitatively the pore size and the pore orientation. In particular the definition of an orientation index (OI) was employed as a means to quantify the orientation of the pore channels inside the scaffolds.

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The aim of this work was to assess the diffusive properties of poly(ethylene glycol) diacrylate (PEGDA)‐based hydrogels, derived from low MW prepolymers, in view of potential biomedical applications. Several hydrogels were synthesized through UV irradiation of PEGDA solutions for different exposure times. Swelling measurements in distilled water were performed to estimate the yielded crosslink density, while swelling tests at 37 °C in selected media allowed to analyze the mesh size changes induced by various pH and ionic strength (IonS) conditions. The transport of glucose and insulin through thin hydrogel membranes was finally assessed in a modified Ussing chamber at physiological values of pH and IonS (7.4 and 150 mM, respectively). Results showed that the swelling was dependent on the IonS (with swelling reductions up to 20–30% for IonS increases in the range 0–300 mM) and, to a lesser extent, on the pH of the surrounding medium (with swelling increments of about 10% for increasing pH in the range 2.5–11). All hydrogels were also permeable to glucose and insulin, which displayed comparable diffusion coefficients (in the order of 10−6 cm2/s). Specific interactions between glucose and the polymer chains were evidenced by values of the partition coefficient higher than unity. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44380.