OBJECTIVES: Diabetes self-management education (DSME) programs are a strategy to maintain healthy behaviors. Nevertheless, limited evidence has been reported from systematic evaluations of the effects of DSME integrated with peer support on glycemic control. This study aimed to review the effectiveness of DSME interventions integrated with peer support on glycemic control in patients with type 2 diabetes.METHODS: A systematic search was carried out in electronic databases, including PubMed, Cochrane Library, ProQuest, SpringerLink, ScienceDirect, Scopus, and Google Scholar, for English-language articles published from 2005 until 2020. The effect size was estimated as the standard mean difference (SMD). The Cochrane Collaboration’s Risk of Bias tool was employed to assess the risk of bias.RESULTS: Twelve studies were included in this study. DSME integrated with peer support effectively reduced glycated hemoglobin A1c (HbA1c) levels, with a statistically significant effect (SMD, -0.41; 95% confidence interval [CI], -0.69 to -0.13; p<0.001). Programs with a sample size <100 (SMD, -0.45; 95% CI, -0.79 to -0.11; p=0.009), duration of intervention ≤6 months (SMD, -0.52; 95% CI, -0.96 to -0.07; p=0.020), baseline HbA1c <8.5% (SMD, -0.42; 95% CI, -0.77 to -0.07; p=0.020), delivery by group (SMD, -0.28; 95% CI, -0.51 to -0.06; p=0.010), and high frequency of contact (SMD, -0.29; 95% CI, -0.48 to -0.10; p=0.003) had statistically significant effects on reducing HbA1c levels in patients with type 2 diabetes.CONCLUSIONS: DSME integrated with peer support effectively enhances glycemic control in patients with type 2 diabetes. Programs with smaller participants groups, shorter interventions, weekly meetings, and closer group sessions improved glycemic control in patients with type 2 diabetes.

Objectives: Depression is a frequent complication of type 2 diabetes mellitus. This study aimed to investigate the relationship between low social support and risk for depression in people with type 2 diabetes through a meta-analysis.Methods: PubMed, ProQuest, SpringerLink, ScienceDirect, Scopus, the Cochrane Library, Embase, and Google Scholar were searched for English-language articles published up to 2021. Pooled adjusted odds ratios (aORs) were calculated using a random-effect model with 95% confidence intervals (CIs). Heterogeneity was evaluated by using the Cochrane Q test and I2 statistics. The risk of publication bias was estimated using a funnel plot, the Egger test, and the Begg test. The Joanna Briggs Institute Critical Appraisal Tools were used to assess the quality of evidence and the risk of bias.Results: Eleven studies were included in this meta-analysis, containing a total of 3151 people with type 2 diabetes mellitus. The pooled analysis showed that people with type 2 diabetes mellitus who had low social support had twice as high a risk of depression as those with high social support (aOR, 2.02; 95% CI, 1.51 to 2.70; p<0.001). A random-effect model was used because the heterogeneity was high (I2= 87%).Conclusions: Low social support was found to increase the risk of depression among people with type 2 diabetes mellitus. Further investigation into factors that may moderate this relationship is required.

Penurunan angka stunting masih menjadi priotitas utama dalam rangka tujuan pembangunan nasional. Indonesia menjadi Negara kedua dengan angka kasus stunting tertinggi kedua di Asia Tenggara setelah kamboja.  Hasil survei Status Gizi Balita Indonesia (SSGBI) pada tahun 2019 menunjukkan bahwa 1 dari 3 anak di Indonesia  terbukti mengalami stunting. Hal ini merupakan masalah serius mengingat sumberdaya yang paling berharga bagi suatu negara adalah sumber daya manusia. Tujuan penelitian ini adalah menganalisis hubungan antara pemantauan pertumbuhan dan pemberian makan oleh pengasuh dengan kejadian stunting pada anak panti asuhan di Kota Semarang tahun 2019. Penelitian ini menggunakan desain kuantitatif analitik melalui pendekatan case control. Populasi dalam penelitian ini adalah seluruh anak panti asuhan di Kota Semarang. Adapun jumlah sampel dalam penelitian ini adalah 48 anak stunting sebagai kelompok kasus dan 48 anak normal sebagai kelompok kontrol dengan rentang usia 8-18 tahun dan diambil secara Purposive sampling. Instrumen penelitian yang digunakan yaitu kuesioner, microtoise dan aplikasi WHO Antro Plus. Analisis data diolah dengan spss menggunakan uji statistik chi square. Hasil penelitian menunjukkan pemantauan pertumbuhan oleh pengasuh tergolong kurang baik (51.04%) dan pemberian makan tergolong kurang baik (54,17%). Uji statistik menunjukkan bahwa kejadian stunting memiliki hubungan yang signifikan dengan pemantauan pertumbuhan (p=0.025) dan pola pemberian makan (p=0.001). Diperlukan pemantauan kesehatan rutin dan edukasi dari petugas puskemas kepada pengasuh tentang cara menentukan status gizi anak dan pola asuh gizi yang benar dan baik.  

III, while 26% have metastases (Yarso et al., 2012). One crucial component of metastasis is the axis stromal cell-derived factor 1α (SDF1a) with its receptor CXCR4 (Chemokine Motif Receptor 4). Some studies suggest

No abstract