Chemotherapy Negates the Effect of SDF1 mRNA to Distant Metastasis and Poor Overall Survival in Breast Cancer Patients

Yarso, Kristanto Yuli; Bellynda, Monica; Azmiardi, Akhmad; Wasita, Brian; Heriyanto, Didik Setyo; Astuti, Indwiani; Hakimi, Mohammad; Aryandono, Teguh

doi:10.31557/apjcp.2021.22.3.757

Cited by 4 publications

(2 citation statements)

References 24 publications

(15 reference statements)

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“…The mechanism of cytotoxic agents causing CIA was described by Luo et al through experiments in experimental animals (C57BL/6 mice) which found the role of inflammation regulation, SDF-1/CXCR4, and cellular apoptosis in the ovarian tissue that played a role in premature ovarian failure [25]. However, Yarso et al found that chemotherapy abolished the effects of SDF1a/CXCR4 in breast cancer patients [26]. This indicates that other factors play a role in the mechanism of ovarian damage due to chemotherapy through complex interactions.…”

Section: Discussionmentioning

confidence: 99%

Age as an Independent Factor in the Permanent Chemotherapy-Induced Amenorrhea Incidence in Breast Cancer Patients at Dr. Moewardi Hospital, Surakarta, Indonesia

Mudib

Yarso

Nugroho

2021

Open Access Maced J Med Sci

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Background: Chemotherapy Induced Amenorrhea (CIA) is one common side effect of chemotherapy in breast cancer patients. Some who have CIA may experience menstruation return while others experience permanent CIA. Aim: to examines the factors that contribute to the incidence of persistent CIA in breast cancer patients. Methods: The population of this retrospective study was new breast cancer patients with premenopausal status when they started receiving chemotherapy at dr Moewardi Hospital Surakarta, Indonesia, from January 2019 to July 2021. To determine the relationship, the chi-square/Fisher’s exact test was performed. Risk factor analysis on the incidence of permanent CIA was carried out by using a bivariate logistic regression test, followed by multivariate analysis. Results: A number of 105 premenopausal breast cancer patients who received chemotherapy were found. Of these patients, 97 (93.38%) patients experienced CIA and 8 patients (6.62%) continued to menstruate. Of all the subjects having CIA, 49 patients (46.67%) menstruated again while the other 48 (45.71%) had persistent CIA. Age factor has a significant relationship with the incidence of permanent CIA (p =< 0.001), where patients aged > 45 years tend to have permanent CIA incidence with a proportion of 42 patients (87.5%) (p < 0.05). The multivariate analysis showed that age > 45 years (OR = 75.117; 95% CI = 12.671-445.311; p = < 0.001) was the most dominant risk factor associated with the incidence of permanent CIA, while other variables as risk factors for permanent CIA based on multivariate analysis were Stage III (R = 6.677; 95% CI = 1.370-32,545; p = 0.019) compared to stages I and II, and BMI in the normal category (OR = 5.485; 95% CI = 1.083-27.786; p = 0.040) compared to excess BMI. The other variables were not found to be associated with the incidence of permanent CIA. Conclusion: Age is a major factor associated with permanent CIA incidence. Other factors related to this study are staging and BMI. Keywords: Age, Permanent, Chemotherapy Induced Amenorrhea, Breast Cancer

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Section: Discussionmentioning

confidence: 99%

Age as an Independent Factor in the Permanent Chemotherapy-Induced Amenorrhea Incidence in Breast Cancer Patients at Dr. Moewardi Hospital, Surakarta, Indonesia

Mudib

Yarso

Nugroho

2021

Open Access Maced J Med Sci

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“…Breast cancer is a common and debilitating disease that affects millions of women worldwide.1 It causes significant physical, emotional, and psychological challenges for those who are diagnosed. Patients with breast cancer frequently need breast reconstruction surgery [ 1 , 2 ]. Breast reconstruction is an important part of the overall treatment and recovery process of breast cancer because it aims to restore the form, shape, and symmetry of the breast following a mastectomy [ 1 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Patients’ Satisfaction After Breast Reconstruction Surgery Using Autologous versus Implants: A Meta-Analysis

Sungkar,

Yarso,

Nugroho

et al. 2024

Asian Pac J Cancer Prev

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Introduction: Breast cancer is a common disease that affects women globally and causes physical and emotional challenges. Breast reconstructive surgery aims to restore the shape of the breast after a mastectomy. Two common approaches used today are tissue-based or autologous and implant-based reconstruction. Autologous breast reconstruction has the advantage of being more affordable, but the resulting shape is less attractive. At the same time, the implant technique produces a more pleasing shape at a more expensive cost. Objective: To compare the level of patients’ satisfaction after breast reconstruction using the implant technique with the autologous technique using the Breast-Q questionnaire. Methods: This research was a meta-analytic study to compare patients’ satisfaction levels with breast reconstruction using the autologous technique compared with the implant technique. We searched several research articles from PubMed, EMBASE, and the Cochrane Library from 2014 to 2023. Then, we conducted an analysis using Revman 5.4. The results of the study were presented in a forest plot diagram. Results: From the search results, there were 3980 studies. Then, exclusion and inclusion were carried out, and the results obtained were 16 research articles. Of the 16 studies, analysis was then carried out, and the results obtained were satisfaction in breast patients with a sample size of 7284. The standard result of the mean difference was 0.55 (95% CI 0.41-0.68) p < 0.00001. Satisfaction with the reconstruction results with a sample size of 2935. The standard result of the mean difference was 0.48 (95% CI 0.28-0.69) p < 0.00001. Patients’ sexual satisfaction with a sample size of 7149. The standard result of the mean difference was 0.27 (95% CI 0.17-0.37) p < 0.00001. Patients’ satisfaction with nipple shapes with a sample of 426. The standard result of the mean difference was 0.22 (95% CI -0.00-0.44) p = 0.06. Patients’ satisfaction with plastic surgeons with a sample size of 272. The standard result of the mean difference was 0.52 (95% CI 0.25-0.80) p= 0.0002. Conclusion: The autologous breast reconstruction technique is better than the implant-based reconstruction technique in terms of patient satisfaction with the breast, reconstruction outcome, sexual satisfaction, nipple shapes, and plastic surgeons based on the Breast-Q questionnaire. The findings of this comprehensive study indicate that breast cancer survivors who choose autologous reconstruction have higher levels of satisfaction across multiple domains than those who decide implant-based reconstruction.

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The nanobody targeting PD-L1 and CXCR4 counteracts pancreatic stellate cell-mediated tumour progression by disrupting tumour microenvironment

Li,

Zheng,

et al. 2024

International Immunopharmacology

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Chemotherapy Negates the Effect of SDF1 mRNA to Distant Metastasis and Poor Overall Survival in Breast Cancer Patients

Abstract: III, while 26% have metastases (Yarso et al., 2012). One crucial component of metastasis is the axis stromal cell-derived factor 1α (SDF1a) with its receptor CXCR4 (Chemokine Motif Receptor 4). Some studies suggest

Cited by 4 publications

References 24 publications

Age as an Independent Factor in the Permanent Chemotherapy-Induced Amenorrhea Incidence in Breast Cancer Patients at Dr. Moewardi Hospital, Surakarta, Indonesia

Age as an Independent Factor in the Permanent Chemotherapy-Induced Amenorrhea Incidence in Breast Cancer Patients at Dr. Moewardi Hospital, Surakarta, Indonesia

Patients’ Satisfaction After Breast Reconstruction Surgery Using Autologous versus Implants: A Meta-Analysis

The nanobody targeting PD-L1 and CXCR4 counteracts pancreatic stellate cell-mediated tumour progression by disrupting tumour microenvironment

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