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Prostatic parenchymal calculi are common, usually incidental, findings on morphological examinations. They are typically asymptomatic and may be present in association with normal glands, benign prostatic hyperplasia, and prostate cancer. However giant prostatic calculi are rare. Less than 20 cases have been reported in the literature. We present the case of a 35-year-old man with two giant prostatic calculi that replaced the entire gland. He underwent an open cystolithotomy, two giant stones were removed from the prostate, and we used a lithotripsy in situ for extraction of stone fragments.

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The simultaneous presence of primary carcinomas in the same patient is uncommon and synchronous primary tumors involving the kidney and pancreas are extremely rare. There are a few reports in the English literature of synchronous primary malignancies of the kidney and pancreas. We present a 62-year-old man who had weight loss of 9 kg and epigastric pain. Findings showed a Furhman grade II renal papillary carcinoma confined to the kidney and a synchronous well differentiated pancreatic ductal adenocarcinoma.

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A 65-year-old man with no notable medical history presented to the urology clinic with swelling in the area of the left testicle that had started 4 weeks earlier. Examination of the scrotum revealed an enlarged varicose vein along the left spermatic cord (Panel A, arrows), and abdominal palpation revealed a mass in the right flank. Computed tomography of the abdomen and pelvis revealed multiple bilateral renal tumors (Panel B, arrows), with the largest tumor located in the left kidney. Open radical nephrectomy of the left kidney was performed, and the results confirmed the diagnosis of renal-cell carcinoma. One week later, the varicocele disappeared. A varicocele is a dilatation of the pampiniform plexus of the spermatic cord; this network of veins is dependent on the spermatic vein. Varicocele occurs more commonly on the left side because the spermatic vein opens at a sharp angle into the left renal vein, whereas the right spermatic vein opens into the larger inferior vena cava. An acute nontraumatic varicocele, especially on the left side, may indicate the presence of a retroperitoneal mass.

The finding of prostate cancer after a cystoprostatectomy for a bladder tumour can occur in up to 70% of cases. The incidence of prostate cancer in patients with a bladder tumour is 18 times higher than in the general population; moreover, the incidence of bladder cancer in patients with prostate cancer is 19 times higher than in the general population. This association can be explained by the common embryological origin of these organs, with molecular similarities. Other similarities between these two cancers are noted. They are multifocal and may be secondary to urinary stasis. However, this association does not seem responsible for an increased risk of progression of both diseases. The prognosis is related to the extension of each cancer. The stage and grade of bladder cancer are, in terms of prognosis, greater than those of prostate cancer. Most often, this is insignificant prostate cancer. Despite this, the prostate-specific antigen test should be administered to monitor patients after cystoprostatectomy.