Synchronous primary malignancies of the male urogenital tract

Abstract

The finding of prostate cancer after a cystoprostatectomy for a bladder tumour can occur in up to 70% of cases. The incidence of prostate cancer in patients with a bladder tumour is 18 times higher than in the general population; moreover, the incidence of bladder cancer in patients with prostate cancer is 19 times higher than in the general population. This association can be explained by the common embryological origin of these organs, with molecular similarities. Other similarities between these two cancers are noted. They are multifocal and may be secondary to urinary stasis. However, this association does not seem responsible for an increased risk of progression of both diseases. The prognosis is related to the extension of each cancer. The stage and grade of bladder cancer are, in terms of prognosis, greater than those of prostate cancer. Most often, this is insignificant prostate cancer. Despite this, the prostate-specific antigen test should be administered to monitor patients after cystoprostatectomy.

Carcinoma Prostate With Carcinoma Penis: Rare Case of Dual Primary Urological Malignancy

“…The nding of prostate cancer after a cystoprostatectomy for a bladder tumour can occur in up to 70% of cases. The incidence of prostate cancer in patients with a bladder tumour is 18 times higher than in the general population (7). To the best of our knowledge a synchronous malignancy of CA Penis and CA prostate has not yet been reported.…”

Prevalence and clonality of synchronous primary carcinomas in the bladder and prostate

“…Previous retrospective studies have mainly centered on the clinicopathological features of IPCa in BCa cystoprostatectomy specimens, and different reports reached varied conclusions . In this study, we have presented the largest Asian cohort of 919 BCa cases and a systematic meta‐analysis of 19 868 patients who received radical cystectomy for bladder cancer.…”

“…Despite extensive previous investigations and emerging consensus on the paramount importance of precise diagnosis, the prevalence, pathological characteristics, clinical significance, and standardized management of synchronous primary carcinomas in the bladder and prostate remain unclear and often controversial in the literature . In addition, the relationships between concomitant IPCa and BCa and their molecular origins have not been comprehensively characterized . Therefore, we reasoned that a systematic meta‐analysis in combination with a detailed genomic description might enhance our understanding of the clinical relevance and genetic relatedness of simultaneous BCa and IPCa in a given patient.…”

Non-Epstein-Barr Virus Sinonasal Undifferentiated Carcinoma Presenting as Diplopia and Rhinorrhea

“…Additionally, our patient also has a previous history of bladder cancer, however, the incidence of having primary bladder cancer with primary sinonasal cancer is also uncommon, although there are a few reported cases of metastasis between the bladder and sinuses [ 10 , 11 ]. Sinonasal cancer is usually found alongside paranasal cancers, lung cancer, and bone cancer, whereas bladder cancer is found alongside lung, bone, prostate, and liver cancer [ 12 , 13 ]. However, it should be noted that there is currently limited literature to confirm that a history of bladder cancer may be associated with an increased risk of developing sinonasal cancer.…”