Synchronous primary tumors of the kidney and pancreas: Case report

Ismail, T. Ould; Janane, A.; Hajji, F.; Dekkak, Y.; Bekkali, S.; Sossa, J.; Chafiki, J.; Eloundou, J.; Lahrech, Y.; Qamous, O.; Qarro, A.; Jira, H; Ghadouane, M.; Ameur, A.; Albouzidi, A.; Abbar, M.

doi:10.1007/s12301-010-0027-2

Cited by 3 publications

(5 citation statements)

References 7 publications

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“…Multiple primary cancers (MPC) in the same patient are rare, but synchronous MPC are exceptional [ 1 , 2 ]. Most synchronous tumors involve both the gastrointestinal and the genitourinary tract, followed by the breast and gastrointestinal tract or the breast and genitourinary tract [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, there has been only infrequent reporting of synchronous or metachronous tumors of the kidney and the pancreas [ 1 , 2 , 3 , 4 ]. In 1969, Sasaki et al [ 5 ] reported the first case of an association between renal and pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Studies examining genetic factors found that microsatellite instability was more frequently observed in MPC than in sporadic cancer [ 3 ]. Another study reported a mutation in codon 12 of the K- ras gene in a patient with synchronous tumors of the kidney and pancreas [ 2 ]. In our case, molecular investigations were not considered because of the absence of known familial genetic syndromes, but genetic analysis of synchronous tumors in different organs may provide information about the etiology of genetic changes that occur during carcinogenesis [ 1 , 2 , 3 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Multiple primary malignancies are uncommon (1–3% of all cancers), but synchronous multiple primary tumors are extremely rare, and synchronous primary tumors involving the kidney and pancreas are exceptional and poorly documented [ 1 , 2 ]. Indeed, there are only a few reports of this situation in the English literature.…”

Section: Introductionmentioning

confidence: 99%

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Synchronous Primary Renal Cell Carcinoma and Pancreatic Ductal Adenocarcinoma: Case Report and Literature Review

Mahfoud¹,

Tanz²,

Khmamouche³

et al. 2017

Case Rep Oncol

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Synchronous primary cancers involving the pancreas and kidney are extremely rare and poorly documented. We report the first case of this association treated with chemotherapy and tyrosine kinase inhibitor. A 70-year-old woman presented with a 2-month history of epigastric pain with weight loss of 12 kg. Two weeks previously, she had presented with jaundice and pelvic pain. A computed tomography (CT) scan of the body revealed the presence of an irregular mass in the body of the pancreas, encasing the celiac trunk, with dilatation of the biliary tract. CT also revealed a heterogeneously right renal mass with bone metastasis in the left acetabular cup and the left iliac wing. A biliary metallic prosthesis was performed with a pancreatic mass biopsy. Histology revealed a moderately differentiated pancreatic ductal adenocarcinoma. Another biopsy was performed in the right iliac wing. Pathological examination with immunohistochemistry confirmed the diagnosis of bone metastasis from clear cell renal cell carcinoma. The patient was treated with a combination of gemcitabine, sunitinib, and denosumab. She had a stabilization disease and a prolonged progression-free survival of 9 months. Side effects were manageable and included grade 2 fatigue and grade 2 hypertension. The patient died at 13 months from diagnosis after disease progression. This report suggests that the appropriate treatment for this association in metastatic or unresectable disease is chemotherapy for pancreatic cancer and tyrosine kinase inhibitor for kidney cancer. We also review the appropriate literature concerning that association.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synchronous Primary Renal Cell Carcinoma and Pancreatic Ductal Adenocarcinoma: Case Report and Literature Review

Mahfoud¹,

Tanz²,

Khmamouche³

et al. 2017

Case Rep Oncol

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show abstract

“…Although pancreatic and kidney cancers are known to be independent, a crucial step in the diagnosis process of synchronous MPT is to eliminate a possible connection between the two different tumors [5]. Interesting genetic analysis of patients with concomitant pancreatic and renal cancers demonstrated microsatellite instability and mutations of codon 12 of k-ras gene [6,7]. Overall, the management plan of synchronous tumors is dictated by the staging of each primary tumor.…”

Section: Discussionmentioning

confidence: 99%

A Two-Front War : Targeting Synchronous Metastatic Pancreatic and Renal Cell Carcinomas with the Combination of Gemcitabine and Sunitinib

Assi¹,

Rassy²,

Moussa³

2017

LMJ

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Pancreatic ductal adenocarcinoma concomitant with pancreatic metastases of clear-cell renal cell carcinoma: a case report

et al. 2021

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Background Metastatic spread to the pancreas is a rare event. Renal cell carcinoma represents one possible site of origin of pancreatic metastases. Renal cell carcinoma often metastasizes late and exclusively to the pancreas, suggesting a special role of renal cell carcinoma among primaries metastasizing to the pancreas. Even rarer, renal cell carcinoma may occur simultaneously with pancreatic ductal adenocarcinoma. Case presentation We present the case of a 78-year-old male Caucasian patient with a history of clear-cell renal cell carcinoma treated with oncological left nephrectomy 20 years before. The patient was diagnosed with pancreatic ductal adenocarcinoma by fine-needle aspiration cytology. At our institution, he received neoadjuvant therapy with folic acid, fluorouracil, irinotecan, oxaliplatin for borderline-resectable pancreatic ductal adenocarcinoma, and subsequently underwent total pancreatectomy. Upon resection, pancreatic ductal adenocarcinoma as well as two metachronous metastases of clear-cell renal cell carcinoma occurring simultaneously and cospatially with pancreatic ductal adenocarcinoma were diagnosed in the pancreatic body. Conclusions Renal cell carcinoma metastases of the pancreas are rare and often occur decades after the initial diagnosis of renal cell carcinoma. The combination of renal cell carcinoma metastases and pancreatic ductal adenocarcinoma is even rarer. However, the possibility should be considered by clinicians, radiologists, and pathologists. The special role of renal cell carcinoma as a site of origin of pancreatic metastasis should be further elucidated.

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Synchronous primary tumors of the kidney and pancreas: Case report

Cited by 3 publications

References 7 publications

Synchronous Primary Renal Cell Carcinoma and Pancreatic Ductal Adenocarcinoma: Case Report and Literature Review

Synchronous Primary Renal Cell Carcinoma and Pancreatic Ductal Adenocarcinoma: Case Report and Literature Review

A Two-Front War : Targeting Synchronous Metastatic Pancreatic and Renal Cell Carcinomas with the Combination of Gemcitabine and Sunitinib

Pancreatic ductal adenocarcinoma concomitant with pancreatic metastases of clear-cell renal cell carcinoma: a case report

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