Le lymphome malin non hodgkinien bilatéral et primitif de la surrénale (à propos d’une observation avec revue de la littérature)

Primary Bilateral Non-Hodgkin's Lymphoma of the Adrenal Gland: A Case Report

“…Less than 70 cases were reported in the literature [5–8]. Men are the most affected with an age interval between 39 and 89 years with a mean 68 years of age.…”

Primary Bilateral Adrenal Non-Hodgkin's Burkitt-Like Lymphoma: A Rare Cause of Primary Adrenal Insufficiency. Case Report and Literature Review

“…Clinically, the disease can manifest with fever (46%), abdominal pain (26%), asthenia, constipation, weight loss (24%) but also with adrenal failure 18,29,35,36,39 or an Addisonian crisis. Adrenal failure occurs when the parenchymal loss is more than 90% and can improve with the destruction of lymphomatous tissue at the end of a chemotherapy cycle.…”

“…Generally, laboratory tests show an increase in ESR, PCR, WBC, LDH, serum sodium concentration, urea concentration, serum potassium concentration and ACTH, together with a considerable decrease in serum sodium concentration and cortisol concentration 18,29,35,36,38,40 .…”

“…Radiotherapy is also used, but in a very limited number of cases and very often in addition to chemotherapy 5,21,29,36 ; moreover, the results appear to be ineffectual 9,44 .…”

Primary Adrenal Lymphoma

“…This decision was based on the results of study LNH87-2 of the Adult Lymphoma Study Group (French: Groupe d’Etudes des Lymphomes de l’Adulte) before the rituximab era [12]. In the literature, about 70 cases were published with rare complete or partial responses, with an overall survival of 4 months [10,11,12,13]. Kim et al reported recent data about 14 PAL patients treated with an R-CHOP regimen.…”