Primary non-Hodgkin’s lymphoma of the adrenal gland is rare. We report the case of a 56-year-old patient suffering from B symptoms. The CT scan showed a bilateral adrenal mass without any lymph nodes. Scan-guided biopsies led to the diagnosis of diffuse large B-cell lymphoma. The medullar biopsy eliminated a secondary lymphoma. The patient was treated by immunochemotherapy with a complete response before autologous stem cell transplantation.
Digital ulcers (DU) are a well-known problem in patients with systemic sclerosis. It is an underestimated complication of the disease causing pain and morbidity. Essential thrombocytosis is another cause of DU. The association of theses two diseases increases the risk of ischemic complications and impairment of hand function which are frequently observed in patients with digital ulcers. This report deals with a 68-year-old patient with rare association of Essential thrombocytosis ,Systemic sclerosis and Raynaud's phenomenon that was refractory to medical treatment of Systemic sclerosis (illoprost,calcium channel blockers) and improved with hydrea R .
Plasmablastic myeloma is an atypical variant of multiple myeloma with a poor prognosis. We report a case of a 59-year-old-male, who was diagnosed to have plasmablastic myeloma. We emphasize the diagnostic difficulty of this type of myeloma and the therapeutic options.
Angioedema is a condition described as a transient, non-pruritic, non-pitting and self-limiting local swelling of cutaneous and mucosal tissues that completely resolve in 1 to 5 days. Acquired C1-inhibitor deficiency or acquired angioedema (AAE) may be associated with a lymph proliferative disease. We report the case of a 52 year-old man, without medical history, presented recurrent edema affecting the face and the tongue which regressed spontaneously within 8 to 10 days. Serum compliment levels were as follows; CH50: 15 UI/mL (32-58), C4=0.008 g/L (0.162-0.503), C3: 0,846 g/L (0.743-1.62), C1q=84 mg/L (100-250).C1 esterase inhibitor protein level was 190 mg/l (150-350) with a functional rate at 30% (70-130%). Blood count showed leucocytis with lymphocytic predominance. Bone marrow biopsy showed a CD20+B cell non hodgkin lymphoma. The diagnosis of (AAE) revealing a B cell non Hodgkin lymphoma was retained and the patient had been treated by chemotherapy with good clinical course.
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