Epidural myeloid sarcoma as the presenting symptom of chronic myeloid leukemia blast crisis

Slouma, M.; Rahmouni, S.; Dhahri, R.; Khayati, Yasmine; Zriba, Sami; Amorri, Wajdi; Gharsallah, I.; Métoui, L.; Louzir, B.

doi:10.1007/s10067-020-05167-4

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…Myeloid sarcoma has been seen to be sensitive to radiation and chemotherapy; however, relapses are not uncommon. [ 9 ] Other treatment modalities include surgical resection, intrathecal chemotherapy, and allogeneic stem cell transplantation. [ 9 ] The 1-year survival rate with systemic chemotherapy treatment was 46% and only 16% with other treatment modalities.…”

Section: Discussionmentioning

confidence: 99%

“…[ 9 ] Other treatment modalities include surgical resection, intrathecal chemotherapy, and allogeneic stem cell transplantation. [ 9 ] The 1-year survival rate with systemic chemotherapy treatment was 46% and only 16% with other treatment modalities. [ 5 ] Survival rate can vary from a few days to up to several months or years.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] Epidural involvement only occurs in about 0.2% of patients with AML. [ 9 ] Although surgical resection is recommended for symptomatic spinal cord compression, 19.2% of cases report complete remission of CNS myeloid sarcoma following chemotherapy or irradiation. [ 7 ] Here, we report a 87-year-old female with an isolated myeloid sarcoma from T4 to T7 (i.e., with a simultaneous diagnosis of AML) who underwent decompressive spinal surgery.…”

Section: Introductionmentioning

confidence: 99%

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Myeloid sarcoma of the thoracic spine: A case report

Patel

Uzoaru

Sutton

et al. 2023

Surgical Neurology International

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Background: Myeloid sarcoma is an uncommon malignant neoplasm that typically arises at extramedullary sites and is associated with a diagnosis of acute myeloid leukemia. While myeloid sarcoma can involve any organ, central nervous system involvement is rare, particularly in the adult population. Case Description: An 87-year-old female presented with progressive paraparesis of 5 days’ duration. The magnetic resonance imaging (MRI) revealed an epidural tumor from T4 to T7 with cord compression. When she underwent a laminectomy for tumor resection, the pathology revealed a myeloid sarcoma with monocytic differentiation. Although she improved postoperatively, she elected to pursue hospice care and expired 4 months later. Conclusion: Myeloid sarcoma is an uncommon malignant spinal neoplasm rarely seen in adults. For this 87-year-old female, MRI-documented cord compression warranted decompressive surgery. Although this patient did not opt for adjuvant therapy, other patients with such lesions may undergo additional chemotherapy or radiation therapy. Nevertheless, optimal management for such malignant tumor is still undefined.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Myeloid sarcoma of the thoracic spine: A case report

Patel

Uzoaru

Sutton

et al. 2023

Surgical Neurology International

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“…The presentation and diagnosis of MS are often noted in the soft tissue regions of the head and lymph nodes [32]. However, other sites noted as common regions for MS development include connective tissue regions, skin and breast tissues, and the digestive system [33].…”

Section: Presentation Diagnosis and Treatmentmentioning

confidence: 99%

The Progression of Chronic Myeloid Leukemia to Myeloid Sarcoma: A Systematic Review

Arzoun¹,

Srinivasan²,

Thangaraj³

et al. 2022

Cureus

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Chronic myeloid leukemia (CML) is a slow-growing type of cancer that originates in the blood-forming cells of the bone marrow and is caused by a chromosomal mutation that is thought to occur spontaneously. CML could potentially lead to the development of myeloid sarcoma (MS), which is a rare neoplasm composed of immature myeloid cells that could evolve into a tumor mass at any anatomical site other than the bone marrow. MS can develop spontaneously or as a result of another form of myeloid neoplasm. Most instances of CML precede blast phase (BP) within two to three years after the first diagnosis of CML chronic phase (CP) at the age of pre-tyrosine kinase inhibitor (TKI) treatment. MS developing in CML patients during the era of TKI treatment is infrequently mentioned in the literature, primarily in single-case studies. As a result, the prognostic influence of MS in CML patients has not been well investigated. In the age of TKI treatment, it is uncertain whether MS and medullary BP have comparable clinical and prognostic relevance. The precise diagnosis of MS is critical for effective treatment, which is frequently delayed due to a high risk of misdiagnosis.This review focuses on the relationship between the development of MS from CML, and it culminates with recommendations for future hematology practice. A literature search was conducted in multiple databases, and the studies were appraised based on the inclusion and exclusion criteria.Finally, studies to date have shown that the existence of CML and its possible progression to MS in individuals map out the numerous implications this disease has in hematology practice. Though occurrences are uncommon in general, the prognosis for patients is bleak, necessitating the exploration and implementation of diagnostic and therapy advancements. Because there is limited evidence in the literature on its existence in the medullary chronic phase and outcomes in the era of TKI, it must be carefully investigated because it might be the first symptom of progressive illness prior to hematological progression.

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Epidural Nonvertebral Tumors

Akhaddar

2023

Atlas of Sciatica

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Epidural myeloid sarcoma as the presenting symptom of chronic myeloid leukemia blast crisis

Cited by 8 publications

References 37 publications

Myeloid sarcoma of the thoracic spine: A case report

Myeloid sarcoma of the thoracic spine: A case report

The Progression of Chronic Myeloid Leukemia to Myeloid Sarcoma: A Systematic Review

Epidural Nonvertebral Tumors

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