The object of these experiments was to try to discover if there is any definite cycle of development of the trypanosome of Sleeping Sickness in the tsetse fly,
Glossina palpalis
, and if the late or renewed infectivity of the fly coincides with any phase in this development. The mode of experimentation was to feed a cageful of
laboratory-bred
tsetse flies on an animal whose blood contained numerous trypanosomes, and at the end of various times to kill the flies and examine their intestinal contents. This was done for periods of one day, two days, three days, and so on, up to 56 days. The microscopical examination of preparations made from the intestinal contents on the various days gave information as to the number and appearance of the trypanosomes.
Col. Sir D. Bruce and others. 256 [Dec. 18, on the 25th day. One of those in Column II had trypanosomes in the blood the day after treatment and died that day. The results of the combined medication were thus scarcely superior to those of the ethylantimonyl tartrate alone/for though there were fewer recurrences when atoxyl was added, the mortality from poisoning was higher, so that only two survived for two months as against six of those treated with antimony alone. It is possible that by a more accurate adjustment of the two drugs the advantages of diminished recurrence and low toxicity might be combined.
When the Sleeping Sickness Commission passed through Kampala, the native capital of Uganda, at the end of October, 1908, on their way to their camp at Mpumu, they were informed by Sir Apolo Kagwa, K. C. M. G., the Prime Minister, that a new disease had broken out in the province of Ankole, and that many people were sick. This is probably the same disease which was described by Dr. A. G. Bagshawe in 1906. He gives the history and symptoms of nine cases which he saw in Ankole. He concluded that the disease was beri-beri, and states that at one village 25 per cent. of the inhabitants were suffering from a more or less serve form of the disease.
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