The development of
            <i>trypanosoma gambiense</i>
            in
            <i>glossina palpalis</i>

Bruce, David; Hamerton, A. E.; Bateman, H. R.; Mackie, F. P.

doi:10.1098/rspb.1909.0041

Cited by 17 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bruce showed the link between trypanosomiasis and tsetse in his studies on ‘the fly disease’ in South Africa, but Kleine was the earliest investigator to elucidate that Trypanosoma brucei had to complete a set cycle through a tsetse to produce and transmit forms that would infect mammals [4]. Bruce corroborated this finding for T. brucei gambiense , and noted that trypanosomes taken up in a bloodmeal reacquired their infectivity to mammals after a discrete period of at least 12 days within the fly, consistent with a developmental cycle [5]. Bruce went on to describe the developmental stages (morphotypes) present in tsetse, and demonstrated that distinct morphotypes were restricted to different tissues [6].…”

Section: Over a Century Of Discoverymentioning

confidence: 92%

The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly

Sharma

Gluenz

Peacock

et al. 2009

Trends in Parasitology

105

114

View full text Add to dashboard Cite

The first description of African trypanosomes was made over a century ago. The importance of the tsetse in transmission and cyclic development of trypanosomes was discovered soon afterwards, and has been the focus of numerous studies since. However, investigation of trypanosomes in tsetse flies requires high resource investment and unusual patience; hence, many facets of trypanosome biology in the tsetse remain to be characterised despite the long history of research. Here, current knowledge and questions about some of the developmental changes in trypanosomes that occur in tsetse flies are summarised, along with recent technical advances that can now be used to provide some answers.

show abstract

Section: Over a Century Of Discoverymentioning

confidence: 92%

The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly

Sharma

Gluenz

Peacock

et al. 2009

Trends in Parasitology

105

114

View full text Add to dashboard Cite

show abstract

“…During metacylogenesis, the mitochondrion regresses to the single tubule characteristic of BSFs, indicating that mitochondrial function is inhibited; the VSG coat, synthesized from VSG genes in metacyclic-type transcription units (metacyclic expression sites), reappears; endocytosis increases; and the cells reacquire infectivity to mammals (1). Although the intricate nature of trypanosome development in the fly has been recognized formore than a century (2), the molecular mechanisms are still mysterious, due in part to experimental challenges of studying parasites in the fly.…”

mentioning

confidence: 99%

Developmental Progression to Infectivity in Trypanosoma brucei Triggered by an RNA-Binding Protein

Kolev

Ramey-Butler

Cross

et al. 2012

Science

184

259

View full text Add to dashboard Cite

Unraveling the intricate interactions between Trypanosoma brucei, the protozoan parasite causing African trypanosomiasis, and the tsetse (Glossina) vector remains a challenge. Metacyclic trypanosomes, which inhabit the tsetse salivary glands, transmit the disease and are produced through a complex differentiation and unknown program. By overexpressing a single RNA-binding protein, TbRBP6, in cultured noninfectious trypanosomes, we recapitulated the developmental stages that have been observed in tsetse, including the generation of infective metacyclic forms expressing the variant surface glycoprotein. Thus, events leading to acquisition of infectivity in the insect vector are now accessible to laboratory investigation, providing an opening for new intervention strategies.

show abstract

“…The entire tsetse part of the trypanosome lifecycle can take up to three weeks [17,100]. Once the trypanosome has successfully colonised the salivary glands the tsetse remains infective for the rest of its lifespan (up to 4 months) [101,102].…”

Section: (A Higher Resolution/colour Version Of This Figure Is Availa...mentioning

confidence: 99%

Basic Biology of Trypanosoma brucei with Reference to the Development of Chemotherapies

Dean

2021

CPD

View full text Add to dashboard Cite

: Trypanosoma brucei are protozoan parasites that causes the lethal human disease African sleeping sickness, and the economically devastating disease of cattle, Nagana. African sleeping sickness, or Human African Trypanosomiasis (HAT) threatens 65 million people, and animal trypanosomiasis makes large areas of farmland unusable. There is no vaccine and licenced therapies against the most severe, late-stage disease are toxic, impractical and ineffective. Trypanosomes are transmitted by tsetse flies and HAT is therefore predominantly confined to the tsetse fly belt in subSaharan African. They are exclusively extracellular, and they differentiate between at least seven developmental forms that are highly adapted to host and vector niches. In the mammalian (human) host they inhabit the blood, cerebrospinal fluid (late stage disease), skin and adipose fat. In the tsetse fly vector, they travel from the tsetse midgut to the salivary glands via the ectoperitrophic space and proventriculus. Trypanosomes are evolutionarily divergent compared with most branches of eukaryotic life. Perhaps most famous for their extraordinary mechanisms of monoallelic gene expression and antigenic variation, they have also been investigated because much of their biology is either highly unconventional or extreme. Moreover, in addition to their importance as pathogens, many researchers have been attracted to the field because trypanosomes have some of the most advanced molecular genetic tools and database resources of any model system. The following will cover just some aspects of trypanosome biology and how its divergent biochemistry has been leveraged to develop drugs to treat African Sleeping sickness. It is by no means intended to be a comprehensive survey of trypanosome features. Rather, it is hoped that it will present trypanosomes as one of the most fascinating and tractable systems in which to do discovery biology.

show abstract

The development of trypanosoma gambiense in glossina palpalis

Abstract: Development o/* Trypanosoma gambiense Glossina palpalis. 405The Development o f Trypanosoma gambiense in Glossina palpalis.

Cited by 17 publications

References 0 publications

The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly

The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly

Developmental Progression to Infectivity in Trypanosoma brucei Triggered by an RNA-Binding Protein

Basic Biology of Trypanosoma brucei with Reference to the Development of Chemotherapies

Contact Info

Product

Resources

About