For additional evidence that the syndrome was due to cardiac insufficiency, 2 of the dogs were sacrificed for study in heart-lung preparations. Cardiac output was low for both hearts. To obtain cardiac outputs approaching the normal range for fresh heart-lung preparations required extremely high auricular pressure, e.g., 150 to 200 mm of saline.Calculation of the "competence index"( 7) also indicated marked cardiac impairment.The animals were sacrificed 1% to 3 months after pulmonary stenosis was produced. Autopsies revealed dilatation and hypertrophy of the right auricle and ventricle in each dog. The pleural cavity was dry and the lungs normal. The liver was markedly enlarged and congested, and 2 to 5 liters of serosanguinous fluid were found in the peritoneal Summary. -4 form of progressive, chronic, "right-sided" cardiac failure has been produced in dogs by tricuspid valve avulsion and pulmonary artery stenosis. Three dogs so treated developed congestive failure with elevated auricular pressure and distended veins, decreased work tolerance, hepatomegaly, ascites, tachycardia at rest, and a relatively fixed heart rate during exercise. Studies of 2 of the hearts in the heart-lung preparation indicate clearly that cardiac insufficiency was present .We are indebted t o Dr. Eugene M. Landis for suggesting this problem, and for his advice during the work. It is also a pleasure t o thank Dr. Otto Krayer for performing the lieart-lung experiments, and Dr. Cliarles A. Hufnagel for surgical advice and assistance.
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