Excretion of Bilirubin and Bromsulfalein in Bile

Cantarow, A.; Wirts, C. Wilmer; Snape, William J.; Miller, Leon L.

doi:10.1152/ajplegacy.1948.154.2.211

Cited by 32 publications

(11 citation statements)

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“…Corresponding to this increase there was a reciprocal reduction in biliary BSP concentration which, however, was not observed until an additional 2 to 3 ml of the bile had been collected. This volume is somewhat smaller than a previous estimate of about 5 ml for the "dead space" of the canine biliary tract (18), possibly because the common duct and major hepatic ducts were maintained in a collapsed state by continuous aspiration in the present studies. Because of the "dead space" lag between flow and concentration changes, the calculated BSP excretory rate showed an abrupt increase followed by a decrease below the control rate.…”

Section: Calculation Of Tm and Scontrasting

confidence: 71%

Biliary Transport and Hepatic Storage of Sulfo-Bromophthalein Sodium in the Unanesthetized Dog, in Normal Man, and in Patients With Hepatic Disease *

Wheeler¹,

Meltzer²,

Bradley³

1960

J. Clin. Invest.

273

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Section: Calculation Of Tm and Scontrasting

confidence: 71%

Biliary Transport and Hepatic Storage of Sulfo-Bromophthalein Sodium in the Unanesthetized Dog, in Normal Man, and in Patients With Hepatic Disease *

Wheeler¹,

Meltzer²,

Bradley³

1960

J. Clin. Invest.

273

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“…Such a decrease can be interpreted in terms of 'competition' phenomena. 'Competition' has been observed whenever two organic anions presumably excreted in bile through similar pathways are injected simultaneously: dehydrocholate decreases bromsulphalein elimination (Cantarow, Wirts, Snape, and Miller, 1948a); bromsulphalein decreases bilirubin excretion (Cantarow et al, 1948b). Similarly, the present results demonstrate that uranin and rose bengal decrease bile salt excretion.…”

Section: Commentssupporting

confidence: 70%

Effects of rose bengal on bile secretion in the rabbit: inhibition of a bile salt-independent fraction

Dhumeaux¹,

Erlinger²,

Benhamou³

et al. 1970

Gut

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SUMMARY The authors have studied the influence of rose bengal, and, by comparison, of uranin, on choleresis in the rabbit. Uranin induced an increase in bile flow and a decrease in bile salt concentration in bile. These results are consistent with an osmotic mechanism, as proposed by Sperber (1959). By contrast, rose bengal induced a marked decrease in bile flow and an increase in bile salt concentration. In rose bengal-treated animals (30 ,moles per kilogram body weight intravenously), bile flow was 65 % lower and bile salt concentration 95 % higher than in control animals studied during the same periods. The relationship between bile flow and bile salt excretion is consistent in the rabbit, with the existence of a bile saltindependent secretion of 60 mg per minute per kilogram body weight, that is, 60% of bile flow. In rose bengal-treated animals, this fraction was only 15 mg per minute per kilogram body weight. It is concluded that rose bengal inhibits the bile salt-independent fraction.Rose bengal, as other phtalein dyes, is excreted by the liver cells. Its effect on the bile saltindependent fraction suggests that this fraction is secreted by the hepatocytes.In the course of studies on dye elimination by the liver in the rabbit, marked differences have been observed between the effects of various phtalein dyes on bile flow. Uranin, as previously noted by others, Sperber (1959), was choleretic.By contrast, rose bengal induced a marked decrease in bile flow, and studies were therefore 'To whom requests for reprints should be addressed.

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“…Cantarow, Wirts, Snape and Miller (14) and Fauvert (8) suggested that competition for hepatic uptake exists between bilirubin and sulfobromophthalein, the latter being selectively removed. Brauer (16,24), no demonstrable uptake extrahepatic tissues (18), no urinary excretih (18)(19)(20)23), no enterohepatic circulation (16 and no reabsorption in the lymphatic circulatic (19,20).…”

mentioning

confidence: 99%

The Plasma Removal of Indocyanine Green and Sulfobromophthalein: Effect of Dosage and Blocking Agents

Hunton¹,

Bollman²,

Hoffman³

1961

J. Clin. Invest.

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In 1950 Brauer and Pessotti (1) observed that the concentration of sulfobromophthalein in bile reached maximal values which were not influenced by further increments in infusion rate. In 1956 Combes, Wheeler, Childs and Bradley (2) introduced the concept of maximal biliary transport capacity for sulfobromophthalein. It is now generally held that when sulfobromophthalein is infused at a rate that exceeds the maximal biliary transport capacity, the biliary excretion of the dye remains relatively constant.The effect of the initial dosage or infusion rate of sulfobromophthalein on the various parameters measuring hepatic uptake is not so uniformly agreed upon, due in part to confusion about the meaning of the parameters themselves. These include: 1) hepatic extraction-the percentage of dye removed in one passage through the liver; 2) clearance rate-the milliliters of plasma comipletely cleared of dye in 1 minute; and 3) disappearance rate or removal rate-herein defined as the percentage of remaining dye removed each minute. Unless specified, removal rate will not be used to express the number of milligrams removed per minute.Casselman and Rappaport (3), Andrews, Maegraith and Richards (4) and Combes and associates (2) have suggested that hepatic extraction is constant or nearly constant, regardless of dosage or infusion rate. Myers (5) and Cook, Lawler, Calvin and Green (6) observed the exact converse; that is, that extraction became less efficient with increasing dose. Lavers and colleagues (7) found that variation in the initial single dose did not affect the rate of removal of sulfobromophthalein from the plasma. Again, the converse has been reported: Fauvert (8) stated that increasing the initial dose decreased the plasma disappearance rate of the dye.Wheeler and associates (9, 10) recently described the hepatic uptake of sulfobromophthalein under special circumstances in which a constant infusion of dye is in excess of the maximal biliary transport capacity. Under these circumstances a portion of plasma removal of the dye is accounted for by bile excretion; this is a constant. The remainder of the dye taken up by the liver from the plasma is stored in the hepatic cells. These authors have shown that hepatic storage is directly proportional to plasma concentration. Consequently, the higher the plasma concentration, the more milligrams of dye can be stored. Limitations were not observed for any potential maximal capacity for this removal mechanism, but it should be noted that the phenomenon is not rate limited. This description does not apply to the mechanics of removal of a single injection of dye, however, because the storage compartment is empty at the outset and, obviously, no constant proportional relationship between storage and plasma concentration would be possible.Several authors (1,(11)(12)(13) reported that sodium dehydrocholate will slow the removal of sulfobromophthalein from the plasma and will delay its excretion in the bile. Cantarow, Wirts, Snape and Miller (14) and Fauvert (8)

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Excretion of Bilirubin and Bromsulfalein in Bile

Cited by 32 publications

References 0 publications

Biliary Transport and Hepatic Storage of Sulfo-Bromophthalein Sodium in the Unanesthetized Dog, in Normal Man, and in Patients With Hepatic Disease *

Biliary Transport and Hepatic Storage of Sulfo-Bromophthalein Sodium in the Unanesthetized Dog, in Normal Man, and in Patients With Hepatic Disease *

Effects of rose bengal on bile secretion in the rabbit: inhibition of a bile salt-independent fraction

The Plasma Removal of Indocyanine Green and Sulfobromophthalein: Effect of Dosage and Blocking Agents

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