Hormone Excretion in Liver Disease and in Gynecomastia

Hormone Excretion in Liver Disease 1

“…This agrees with the finding of Rupp and associates (24), but is a smaller proportion than that found by Glass, Edmondson, and Soll (2). During the past 10 years, it has become abundantly evident that hydrolysis of steroid conjugates may occur if urine is allowed to remain at room temperature, and even to some extent at 40 C. Therefore, this possibility must be considered in any study involving analysis of the free form.…”

“…The liver function tests were done by standard technics and those used for the above classification included total serum bilirubin, thymol turbidity, 24 The grade of gynecomastia was estimated as 1 to 4 plus on the basis of unilateral or bilateral involvement, the size of the firm "button" of tissue beneath the areola, and the presence or absence of tenderness.…”

“…The apparent lack of correlation in some investigations (24,35) may, in part, be due to regressing gynecomastia being included in the series. In four of our eight cases of gynecomastia, this symptom disappeared within four months of the urine collection period.…”

On Bilharziasis and Male Breast Cancer in Egypt: A Preliminary Report and Review of the Literature

“…Feminisation of males suffering from liver disturbances, due to hyperoestrogenism, appearing as gynaecomastia, testicular atrophy, female distribution of hair, loss of libido and impotence has been repeatedly described (Pincus et al, 1951 ;Long and Simmons, 1951 ;Rupp et al, 1951).…”

The Effect of Estrogen on Water and Electrolyte Metabolism. Ii. Hepatic Disease

“…The findings of increased urinary estrogenic material on bioassay in both chronic (30,31) and acute (32) hepatic disease indicates that estrogen production in these conditions is in fact substantial. SUMMARY 1.…”