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Morphological and quantitative histoenzymological changes in neurons of dog spinal cord and spinal ganglion were studied in acute and chronic experiments with epidural administration of 0.01% clofelin. No morphofunctional changes were revealed after bolus injection of clofelin in a single dose of 6.5 mg/kg. After administration of clofelin in a daily dose of 15 microg/kg for 14 days permeability of capillaries in the nervous tissue decreased at the site of injection, but increased in intact areas. Compensatory changes in energy supply to neurons manifested in activation of aerobic and anaerobic oxidation. Sufficient level of nucleic acids synthesis confirms qualitative validity of nervous cells. Epidural clofelin did not cause dystrophy and necrosis in neurons of the spinal and spinal ganglion.

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Iron deficiency anemia (IDA) is a very common pathological condition during pregnancy and the postpartum period. In the structure of hematological diseases in pregnant women, anemias account for about 90% and in most cases are iron deficient [3, 17, 19]. In the third trimester of pregnancy and in the early postpartum period, almost every woman has a latent iron deficiency, and 3040% develop IDA [4, 15, 16, 20, 26]. According to the Ministry of Health of the Russian Federation, the frequency of IDA in Russia has increased 6.3 times over the past ten years, and in St. Petersburg - almost 2 times. The development of anemia during pregnancy is due to an imbalance of iron in the body and is associated with its increased costs for creating a fetoplacental complex, an increase in iron metabolism and a redistribution of this trace element in favor of the fetus. Iron deficiency in the body of pregnant women and women in childbirth is associated with inadequate replacement of losses due to alimentary and mobilized iron.

This article presents the results of experimental investigation of opioid (opiate analgesics) influence on the nociceptive response of rat’s circulatory dynamics, breath and skeletal muscles tonus. The article demonstrates influence of opiate analgesics on intact and pregnant rat’s amplitude and frequency of uterine activity. The results of investigation of drug-induced effect of opiate analgesics in case of pregnant and in case of act of delivery model pain reaction were also described in this article.

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