Local neurotoxicity of epidural clofelin

Abstract

Morphological and quantitative histoenzymological changes in neurons of dog spinal cord and spinal ganglion were studied in acute and chronic experiments with epidural administration of 0.01% clofelin. No morphofunctional changes were revealed after bolus injection of clofelin in a single dose of 6.5 mg/kg. After administration of clofelin in a daily dose of 15 microg/kg for 14 days permeability of capillaries in the nervous tissue decreased at the site of injection, but increased in intact areas. Compensatory changes in energy supply to neurons manifested in activation of aerobic and anaerobic oxidation. Sufficient level of nucleic acids synthesis confirms qualitative validity of nervous cells. Epidural clofelin did not cause dystrophy and necrosis in neurons of the spinal and spinal ganglion.

The Influence of Adjuvants Used in Regional Anesthesia on Lidocaine-Induced Neurotoxicity In Vitro

“…35 As with epinephrine, the only reported possible cause of neurotoxicity of clonidine may be local vasoconstriction and subsequent altered capillary permeability seen after chronic application. 36 In the present study, clonidine did not alter the toxicity of lidocaine. Again, an in vitro study cannot control for possible effects related to its local vasoconstrictor action.…”