Neuropharmacological study of hemodynamics regulation in pain

Cortical control of nociceptive transmission from the heart

“…Similar data were obtained in experiments with stimulation of somatic nerves or dental pulp [1,2,5,10].…”

“…There is evidence on the existence of corticospinal and corticobulbar projections into the nuclei of posterior columns, trigeminal complex, and dorsal horn of the spinal cord [1,2,7]. Moreover, electrophysiological experiments demonstrated both the inhibitory and facilitating effects of CC stimulation on neuronal activity in these structures [14].…”

“…[4]. Some of these structures, such as SGC, thalamus, and CC play an important role in the transition and processing of nociceptive information [2]. Electrical stimulation of SAN produces afferent burst with a nociceptive component.…”

“…This in- and medulla oblongata (nuclei raphes et al) structures [ 1 ], which play the key role in the natural antinociceptive system [2]. In their turn, these structures control the nociceptive traffic by the descending [2] and rostral [ 12] influences. It is noteworthy that among all examined structures AHP is most strongly affected by CC.…”

“…The agonist of opiate M-receptors morphine considerably potentiated the effect of cortical stimulation, while opiate receptor blocker naloxone antagonized it.Key Words: cerebral cortex; descending control; nociception; heart Clinical practice and physiological experiments demonstrated the important role of the cerebral cortex (CC) in perception and regulation of pain [2,10]. One of the components of cortical antinociceptive mechanism is descending inhibition of the nociceptive traffic from cutaneous or pulpal afferent somatic nerves in the spinal cord and supraspinal structures [1,2,10].…”