Wound healing effects of methanol extract of<i>Laurocerasus officinalis</i>roem

Ayla, Şule; Okur, Mehmet Evren; Günal, Mehmet Yalçın; Özdemir, Ekrem Musa; Polat, Derya Çiçek; Yoltaş, Ayşegül; Biçeroğlu, Özge; Karahüseyinoğlu, Serçin

doi:10.1080/10520295.2018.1539242

Cited by 23 publications

(25 citation statements)

References 28 publications

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“…Different Poloxamer 407, 188 and 338 combinations were tried and evaluated according to their physical appearance and gelation temperature properties. Topical drug administration is the simplest and easiest route for localized drug delivery [21]. Topical administration of antifungal agents could have an increased impact on the antifungal therapy, given that current formulations present lack of efficacy due to the rising antifungal drug resistance [22].…”

Section: Preparation Of In Situ Gel Formulationsmentioning

confidence: 99%

Formulation and Detailed Characterization of Voriconazole Loaded in Situ Gels for Ocular Application

Okur

Yozgatlı²,

Şenyiğit

2020

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Objective: This study was aimed to prepare, characterize and evaluate in situ gel formulation for a sustained ocular delivery of voriconazole. Material and Method: In situ gels were prepared with three different hydrophilic co-polymers: Poloxamer 188, 407 and 388. The formulations were characterized in terms of their clarity, pH, viscosity drug content uniformity and mechanical/rheological properties. Moreover, in vitro drug release and stabilitystudies were performed. Result and Discussion: The results showed that the optimized in situ gel formulation had desired in vitro properties and a good stability over the period of 3 months. Texture profile analysis presented that formulations offered suitable adhesive and mechanical properties. P2-V formulation exhibited pseudoplastic flow and typical gel-type mechanical spectra (G′ > G″) at different frequecy values and at different temperatures. Moreover, all formulations showed a sustained drug release for 24 hours. In conclusion, voriconazole loaded in situ gel could be offered as an encouraging strategy as ocular systems for ocular infections treatment.

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Section: Preparation Of In Situ Gel Formulationsmentioning

confidence: 99%

Formulation and Detailed Characterization of Voriconazole Loaded in Situ Gels for Ocular Application

Okur

Yozgatlı²,

Şenyiğit

2020

Ankara Universitesi Eczacilik Fakultesi Dergisi

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“…Also, free oxygen radicals play an important role in apoptosis and cell proliferation mechanisms. Studies have shown that topical application of antioxidant-containing compounds will be beneficial for wound healing and protecting tissues from oxidative damage 7,22 . In our experiments, the antioxidant effect of the extract was revealed, and the antioxidant capacity was thought to be effective in wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…The proliferation phase consists different stages to protect the barrier function of the tissue and provide protection against fluid loss and bacterial entry. The last stage is the restructuring phase when the wound is finally contracted 7 . Multiple studies have shown that essential oils of various medicinal plants increase the wound healing with active ingredients from aromatic plants and fruits 7,25 .…”

Section: Discussionmentioning

confidence: 99%

“…The last stage is the restructuring phase when the wound is finally contracted 7 . Multiple studies have shown that essential oils of various medicinal plants increase the wound healing with active ingredients from aromatic plants and fruits 7,25 . In this study, we observed that P. vulgare increased wound healing, especially by increasing PDGF.…”

Section: Discussionmentioning

confidence: 99%

“…Plants are used frequently by medical practitioners in wound healing 6 . From past to present, various plants have been used as wound healing agents such as Laurocerasus sp., Capparis sp., and Prunus spinosa 4,7 .…”

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confidence: 99%

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An Alternative Approach to Wound Healing Field with Polypodium Vulgare

Batur¹,

Ayla²,

Sakul³

et al. 2020

MMJ

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Objective In this study, we examined the effects of Polypodium vulgare L. (Polypodiaceae) as a candidate to be used for wound healing scarred area. We investigated the antibacterial, and antioxidant activity of P. Vulgare on both in vivo, and in vitro wound healing using an excisional wound model in mice Method We used 32 Balb-c mice equally divided into four groups: Group 1 control, Group 2 vehicle, Group 3 Polypodium vulgare, and Group 4 Centella asiatica extract (CAE). All treatments were applied topically once in a day. The scar area, percentage wound closure and epithelization time were measured. PDGF, VEGF, and collagen immunohistochemical staining were used for evaluation. Results CAE and P. vulgare extract groups were observed to be more effective than the control and vehicle groups in terms of new vascular, epidermal and granulation tissue organization. PDGF, VEGF, and collagen immunohistochemical staining was stronger in the P.vulgare extract and CAE groups compared to the control and vehicle groups. In the P. vulgare and CAE groups, PDGF staining intensity was stronger than the control and vehicle groups, but VEGF and collagen staining in P. vulgare group was not different from the control group. Conclusion P. vulgare had an effect on the injured area by regenerating the epidermis and increasing vascularization. P. vulgare extract with known antioxidant, and antimicrobial activities may be helpful as a supportive treatment in wound healing.

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