Cistaceae family members occur mostly in temperate and subtropical regions such as European-African and Mediterranean ecosystems 1. Cistus species naturally grown in Turkey are represented by five species and known as ''tüylü laden, pamuklu, pamukluk" 2-4. The natural habitat for Cistus species is the Mediterranean area in Turkey. As a result of various ethnobotanical studies, it is stated that Cistus creticus L. is used for hemostatic and wound healing purposes in different localities in Turkey 4-6. Also, in previous studies shown that C. creticus various extracts have in vitro antibacterial, antifungal, anti-Borrelia, cytotoxic, anti-inflammatory, antiviral, antithrombotic, antiatherogenic, antidiabetic, cytotoxic, antioxidant and antiulcer activities 7-19. Also, the study which is done ABSTRACT Cistus creticus L. is a well-known member of the Cistaceae family. In this present study, methanol extract of aerial parts of C. creticus was evaluated for its antifungal activity against plant pathogenic fungi such as Fusarium moniliforme NRRL 2374, Fusarium culmorum NRRL 3288, Alternaria alternata ATCC 6663, and Botrytis cinerea AHU 9424, respectively. The in vitro antifungal activity of C. creticus extract was determined by calculating mycelial growth inhibition. It was demonstrated that methanol extract of C. creticus has shown antifungal activity on F. moniliforme (36,7%) and B. cinerea (30,2%). Moreover, we are planning to evaluate the active fractions which are responsible for the antifungal activity in further studies.
Microbial resistance is an important problem in modern healthcare systems. In addition to drug resistance, the side effects of current antibiotic applications are also known issues. In this present study, binary combinations of amoxicillin with European Pharmacopoeia quality lavender (Lavandula angustifolia) and fennel (Foeniculum vulgare) essential oils were evaluated against human pathogenic microbial strains. The checkerboard method was used to quantify the efficacy of essential oils in combination with amoxicillin. As an initial result, remarkable in vitro antimicrobial activity was observed at relatively low amoxicillin concentrations using different oil combinations against Staphylococcus aureus ATCC 6538, Enterococcus faecalis ATCC 29212, Bacillus cereus ATCC 14579, and Escherichia coli NRRL B-3008, Salmonella typhi (Clinical isolate), respectively. Fractional inhibitory concentrations (FIC) were calculated and interpreted in terms of addition, synergy, antagonism, or indifferent, respectively. A synergistic interaction was shown for E. faecalis and E. coli with the combination F. vulgare essential oil and amoxicillin (FICI= 8.05 x 10-4). Both essential oils together, and in combination with amoxicillin showed a synergistic effect as well.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.