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Objective:The aim of this study was to investigate the interobserver agreement in determination of the dominant histological pattern and the final diagnosis in lung adenocarcinomas. Material and Method:A total of 12 patients with a diagnosis of primary lung adenocarcinoma were included in the study. twelve pathologists from eight study centers were asked first to determine the dominant histological pattern in these cases and then to decide whether the final diagnosis was in situ, minimally invasive or invasive adenocarcinoma. Results:The kappa value for the agreement in determining the dominant pattern among the pathologists was 0.36 (p<0.001), with the values for the lepidic, acinar, papillary, solid, micropapillary patterns and mucinous character of adenocarcinoma being 0.34, 0.28, 0.30, 0.80, 0.16 and 0.38 respectively (p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001). none of the cases was diagnosed as in situ adenocarcinoma. On the other hand, the kappa value for the agreement in differentiating minimally invasive from invasive adenocarcinoma among reviewers was 0.17 (p<0.001). Conclusion:The agreement among pathologists in determining the subtype of lung adenocarcinomas that depends on the identification of the dominant pattern was at intermediate level. In addition, the agreement in deciding whether the case is minimally invasive or invasive, was at low level. The criteria defining the histological patterns should be clarified and described in more detail. Educational activities and larger multicenter studies might be helpful in improving the agreement and standardization. ÖZAmaç: bu çalışmanın amacı, akciğer adenokarsinomunda baskın histolojik patern belirlemede ve nihai tanı konusunda değerlendiriciler arası uyumun araştırılmasıdır. Gereç ve Yöntem:Komplet cerrahi rezeksiyon uygulanan ve mikst tipte primer akciğer adenokarsinom tanılı 12 olgu çalışmaya alındı. Çalışma sekiz merkezden 12 patologun katılımı ile yapıldı. Değerlendiricilerden baskın patern tayini ile son tanı olarak invaziv adenokarsinom, minimal invaziv adenokarsinom arasında seçim yapmaları istendi. Bulgular: Patologlar arasında baskın patern uyumunda kappa değeri 0.36 idi. lepidik, asiner, papiller, solid, mikropapiller ve musinöz paternde uyum sırasıyla 0,34, 0,28, 0,30, 0,80, 0,16, 0,38 (p<0,001, p<0,001, p<0,001, p<0,001, p<0,001, p<0,001) idi. Hiçbir olgu in situ adenokarsinom tanısı almadı. Minimal invaziv adenokarsinom ve invaziv adenokarsinom tanısı için değerlendiriciler arasındaki uyum düşüktü (kappa değeri 0,17 (p<0,001)).Sonuç: Patologlar arası akciğer adenokarsinomunu baskın patern saptamasında uyum orta düzeyde bulundu. Minimal invaziv adenokarsinom ile İAK arası uyum ise düşük düzeyde idi. Histolojik patern kriterleri daha açık ve daha detaylı olarak tanımlanmalıdır. Eğitim programları ve çok merkezli çalışmalar tanıların standardizasyon ve uyumunu geliştirilebilir.

Paragangliomas are neuro-endocrine tumors originating from the adrenal gland. They are usually benign and nonfunctioning, rarely seen in central nervous system. More than 90% of central nervous system paragangliomas are manifested as carotid and glomus jugulare tumors. Spinal paragangliomas are quite rare.The study was conducted through retrospective analysis of the files of the patients who had undergone surgery with pre-diagnosis of spinal intradural tumor between 2011 and 2017 and diagnosed with paraganglioma.A total of 8 patients (4 females and 4 males) were included in the study. Mean age of the patients was 51.1 years (28–64). Time to admission was mean 6.5 months (3 weeks–24 months). Recurrence was not observed in 7 patients, 1 patient is being followed up due to residual tumor.Treatment may be achieved through recognizing malignant transformation in patients who were not diagnosed histopathologically. We consider that quality of life of the patients may be improved through this way.