Formulation and Detailed Characterization of Voriconazole Loaded in Situ Gels for Ocular Application

Okur, Neslihan Üstündağ; Yozgatlı, Vildan; Şenyiğit, Zeynep Ay

doi:10.33483/jfpau.586590

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…With an increase in shear strain the viscosity decreases, as seen in shear thinning. Our findings demonstrated sheer thinning at 37±0.1ºC, in line with the literatures [26][27][28][29]. In our study the G8 formulations gave rise to the highest viscosity value and had the most consistent gel structure.…”

Section: Rheological Studiessupporting

confidence: 92%

Formulation and optimization of gellan gum-poloxamer based dexamethasone mucoadhesive in situ gel

Rençber¹,

Karavana²

2020

jrp

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The main objective of the present study was to formulate and evaluate mucoadhesive in situ buccal gels of dexamethasone based on gellan gum-poloxamer 407. Formulations were characterized for gelling capacity, drug content, pH, viscosity, rheological studies, mechanical studies and in vitro drug release. The drug content, clarity and pH of the formulations were found to be satisfactory. Mucoadhesive in situ gels showed thermoresponsive behavior, existing as a liquid at room temperature and gel at 30-37ºC. Formulations exhibited pseudoplastic flow and typical gel-type mechanical spectra (G′ > G″) at different frequecy values and 37ºC. Prepared gels resulted in preparations with desirable rheological features as well as texture (appropriate hardness, compressibility, adhesiveness, cohesiveness and elasticity) properties, which could benefit the therapeutic efficacy, by increasing the residence time and easiness for local application on the buccal mucosa. Additionally, the developed preparations exhibited sustained drug release up to 72 h as intended for these systems. Optimized formulation containing 14% w/v poloxamer 407 and 0.4% w/v gellan gum exhibited desired characteristics (mechanical and rheological properties) for developing buccal drug delivery systems. Thus, buccal dexamethasone loaded mucoadhesive in situ gel was found to be a promising formulation.

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Section: Rheological Studiessupporting

confidence: 92%

Formulation and optimization of gellan gum-poloxamer based dexamethasone mucoadhesive in situ gel

Rençber¹,

Karavana²

2020

jrp

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“…The optimized in situ gel underwent gelation within 1.233 ± 0.058 s at 32.200 ± 0.265 • C. Particularly, the addition of poloxamer 188 lengthened the gelation time and increased the gelling capacity. Similar in vitro release study results were observed in which the formulations showed sustained release up to 24 h [34]. Nonetheless, in vivo studies for ocular irritation and retention, and ex vivo permeation studies had not been conducted in this study compared to the previous study.…”

Section: Ocular Fungal Infectionssupporting

confidence: 80%

“…Nonetheless, in vivo studies for ocular irritation and retention, and ex vivo permeation studies had not been conducted in this study compared to the previous study. In addition, both studies [ 33 , 34 ] had not conducted in vivo antimicrobial efficacy to show the potential clinical use of the novel formulations.…”

Section: Smart Ocular Delivery Using Stimuli-responsive In Situ Gel Platformmentioning

confidence: 99%

Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research

et al. 2021

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Eyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes are exposed directly to the external environment; they are susceptible to the vicissitudes of diseases. The World Health Organization has predicted that the number of individuals affected by eye diseases will rise enormously in the next decades. However, the physical barriers of the eyes and the problems associated with conventional ocular formulations are significant challenges in ophthalmic drug development. This has generated the demand for a sustained ocular drug delivery system, which serves to deliver effective drug concentration at a reduced frequency for consistent therapeutic effect and better patient treatment adherence. Recent advancement in pharmaceutical dosage design has demonstrated that a stimuli-responsive in situ gel system exhibits the favorable characteristics for providing sustained ocular drug delivery and enhanced ocular bioavailability. Stimuli-responsive in situ gels undergo a phase transition (solution–gelation) in response to the ocular environmental temperature, pH, and ions. These stimuli transform the formulation into a gel at the cul de sac to overcome the shortcomings of conventional eye drops, such as rapid nasolacrimal drainage and short contact time with the ocular surface This review highlights the recent successful research outcomes of stimuli-responsive in situ gelling systems in treating in vivo models with glaucoma and various ocular infections. Additionally, it also presents the mechanism, recent development, and safety considerations of stimuli-sensitive in situ gel as the potential sustained ocular delivery system for treating common eye disorders.

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“…2 ml of sample was taken at a predetermined times from 30 min to 48 h and the same volume of fresh medium was replaced. The samples were analyzed with UV for determination of the drug content [36].…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization

SIAFAKA,

YAĞCILAR,

GÜVEN

et al. 2024

jrp

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Ocular drug delivery of any molecule is quite complex and challenging due to the ophthalmic anatomy. The current ocular formulations such as drops, gels or ointments cannot deliver the active molecules efficiently, therefore newer dosage forms are being developed. In situ gels which are in the liquid state in room temperature or in certain pH but transform to gels when instilled onto the eye belongs to such innovative dosage forms. Herein, the fabrication of in situ gels for naringin ocular delivery is presented since there are very few studies examining the use of naringin as an active molecule for eye delivery. Naringin which is hydrolyzed in naringenin, is a flavonoid glucoside found on citrus fruits and has been studied as antioxidant and anti-inflammatory agent or potent antimicrobial agent. The naringin loaded in situ gels developed via cold method using Poloxamer 407, sodium alginate and hydroxypropyl methylcellulose E5. The temperature-responsive in situ gels were characterized for clarity, sol-gel transition temperature, gelling capacity, pH and viscosity. All the results were of desirable limits. Furthermore, in vitro drug release demonstrated that the in situ gels showed sustained pattern Antimicrobial studies indicated specific antimicrobial potency against Enterococcus faecalis. Future studies will involve in vivo studies and ocular irritation analysis.

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Formulation and Detailed Characterization of Voriconazole Loaded in Situ Gels for Ocular Application

Cited by 8 publications

References 29 publications

Formulation and optimization of gellan gum-poloxamer based dexamethasone mucoadhesive in situ gel

Formulation and optimization of gellan gum-poloxamer based dexamethasone mucoadhesive in situ gel

Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research

In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization

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