Vitamin-E metabolism and its application

Thakur, M.L.; Srivastava, Uma

doi:10.1016/0271-5317(96)00196-0

Cited by 28 publications

(14 citation statements)

References 168 publications

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“…Vitamin E is the main antioxidant responsible for protecting the membranes against lipid peroxidation. In humans, vitamin E deficiency may cause neurological dysfunction, myopathies and decreased erythrocyte life (40) .…”

Section: Introductionmentioning

confidence: 99%

Nutritional status of patients with biliary atresia and autoimmune hepatitis related to serum levels of vitamins A, D and E

Saron

Godoy

Hessel

2009

Arq. Gastroenterol.

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-Context -Chronic liver disease may induce to malabsorption of lipids and fat-soluble vitamins, leading to injury of nutritional status. Objectives -To evaluate the nutritional status of pediatric-age patients with autoimmune hepatitis and biliary atresia related to serum levels of vitamins A, D and E and the disease severity. Methods -This controlled transverse study, evaluated the patients with autoimmune hepatitis and biliary atresia and a reference group paired by sex and age. The patients underwent anthropometric evaluation, alimentary inquiry and determination of serum levels of vitamins A, D and E by high performance liquid chromatography. The Mann-Whitney test, Spearman correlation coefficients and variance analysis (ANOVA) were utilized for data treatment, regarding significant difference if P<0.05. Results -The highest nutritional deficit was observed in patients with biliary atresia, mainly with cholestasis. The serum levels of vitamins A and E for the reference group changed as a function of age. The serum levels of vitamins A, D and E were higher in reference group than in patients with biliary atresia and autoimmune hepatitis together or separately. There were not difference in the serum levels of vitamins A, D and E between biliary atresia groups with cholestasis and without cholestasis. It was verified correlation between weight/age, triceps skinfold thickness, subscapular skinfold thickness, midarm circumference, midarm fat area values and vitamin A serum levels, as well as between all anthropometric indicators and vitamin E in patients with autoimmune hepatitis and biliary atresia. Conclusion -The patients with biliary atresia and cholestasis presented the highest nutritional injury. The patients with biliary atresia and autoimmune hepatitis presented lower serum levels of vitamins A, D and E that in control group. There is a directly proportional correlation between vitamin serum levels, mainly vitamin E, and all anthropometric variables of biliary atresia and autoimmune hepatitis groups.

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Section: Introductionmentioning

confidence: 99%

Nutritional status of patients with biliary atresia and autoimmune hepatitis related to serum levels of vitamins A, D and E

Saron

Godoy

Hessel

2009

Arq. Gastroenterol.

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“…A vitamina E é a principal vitamina lipossolúvel responsável por proteger a membrana celular da peroxidação lipídica (THAKUR; SRIVASTAVA, 1996). Especialmente a forma α-tocoferol tem a maior biopotência.…”

Section: Estresse Oxidativounclassified

Selenium and Vitamin in Diets for Tilapia-Do-Nilo

Botelho

Leira²,

Melo³

et al. 2017

Nucleus

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RESUMO:Dentre as espécies de peixes que demonstram potencial para o cultivo no Brasil, a tilápia-do-Nilo (Oreochromis niloticus) é considerada a espécie mais produtiva. Essa espécie apresenta diversas vantagens, entre elas: rápido crescimento, maior rendimento de filé, resistência a baixa qualidade de água e boa aceitação no mercado consumidor. Na nutrição de peixes vários são os aspectos a serem avaliados em uma ração. O selênio e a vitamina E fazem parte de um sistema de defesa antioxidante multicomponente. Este sistema protege as células contra os efeitos adversos das espécies reativas de oxigênio e outros radicais livres que iniciam a oxidação. Além disso a suplementação de Vitamina E na dieta proporciona um maior desempenho produtivo, efeitos positivos nos parâmetros imunológicos dos peixes e resistência ao estresse. O selênio é um elemento que possui margem estreita entre os níveis de exigência e toxidez. As exigências são baixas, mas se não atingida, podem comprometer o sistema antioxidante e causar graves consequências para o metabolismo do animal. A capacidade do peixe em acumular selênio nos tecidos pode tornar a carne de pescado um interessante alimento funcional para a nutrição humana, especialmente como boa fonte de selênio. A tilápia-do-Nilo tem um nível de exigência específica de selênio e vitamina E que não pode ser satisfeito somente pelo ambiente aquático. Desta forma uma correta suplementação na dieta de minerais e vitaminas poderá garantir um maior desempenho, proporcionando uma melhor qualidade de carne e melhor aceitação no mercado.Palavras-chave: Antioxidante. Aquicultura. Imunológicos SELENIUM AND VITAMIN IN DIETS FOR TILAPIA-DO-NILO SUMMARY:Among the species of fish that demonstrate potential for cultivation in Brazil, Nile tilapia (Oreochromis niloticus) is considered the most productive species. This species has several advantages, including: rapid growth, increased fillet yield, low quality water resistance and good acceptance in the consumer market. In fish nutrition there are several aspects to be evaluated in a ration. Selenium and Vitamin E are part of a multicomponent antioxidant defense system. This system protects the cells against the adverse effects of reactive oxygen species and other free radicals that initiate oxidation. In addition, supplementation of Vitamin E in the diet provides greater productive performance, positive effects on immunological parameters of fish and resistance to stress. Selenium is an element that has a narrow margin between the levels of demand and toxicity. The requirements are low, but if not achieved, could compromise the antioxidant system and cause serious consequences for the animal metabolism. The fish's ability to accumulate selenium in tissues can make fish fillet an interesting functional food for human nutrition, especially as a good source of selenium. Nile Tilapia has a level of specific requirement of selenium and vitamin E that cannot be satisfied only by the aquatic environment. Thus a correct supplementation of minerals and vitamins ...

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“…It can react with free radicals and protect membrane unsaturated lipids and proteins from oxidation (Clycombe andMeydani 2001, Gü rbay et al 2006). The antioxidative effect of tocopherol results from its participation in scavenging free radicals and termination of lipid peroxidation (Thakur and Srivatsava 1996) and it can protect cells and their structures from oxidation (Kalender et al 2004). The efficiency of tocopherol in the reduction of oxidative stress is depended on the dose of vitamin used.…”

Section: Introductionmentioning

confidence: 99%

The influence of α-tocopherol supplementation on plasma concentration of this vitamin and insulin in sedentary or physically trained rats

Debski

Gralak²,

Gronowska-Senger³

et al. 2011

Polish Journal of Veterinary Sciences

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Male young growing rats of Wistar strain (n=54) were fed a vitamin E deficient diet for 3 days of adaptation period and then 10 days of experimental period. After adaptation half of the rats ran, once per a day, on a treadmill with a rate of 2.0 m/s for 15 minutes for the following 10 days. Animals were given orally 0, 0.5, 1.0 or 4.0 mg/d/rat of α-tocopherol. The aim of the study was to evaluate the influence of physical training on tocopherol and insulin concentrations in the blood plasma of rats treated with different doses of vitamin E. The concentrations of α-tocopherol (HPLC-UV method used) and insulin (rat insulin specific RIA method used) were estimated in the blood plasma. Lower concentration of vitamin E in physically trained animals was observed, which may suggest increased needs of organisms for antioxidants, as a result of increased free radical production. In trained rats a lower concentration of plasma insulin was also observed. This effect is probably related to improvement in insulin action observed in organisms under physical exercise. The most significant impact on plasma α-tocopherol was due to its supplementation level. The treatment of rats with different doses of α-tocopherol was found to be not related to insulin concentration in plasma. A significant increase in feed conversion factor was noted in vitamin E treated animals. The obtained results suggest that the increased requirement of trained rats for antioxidants might be covered by α-tocopherol supplementation.

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Vitamin-E metabolism and its application

Cited by 28 publications

References 168 publications

Nutritional status of patients with biliary atresia and autoimmune hepatitis related to serum levels of vitamins A, D and E

Nutritional status of patients with biliary atresia and autoimmune hepatitis related to serum levels of vitamins A, D and E

Selenium and Vitamin in Diets for Tilapia-Do-Nilo

The influence of α-tocopherol supplementation on plasma concentration of this vitamin and insulin in sedentary or physically trained rats

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