Upper gastro-intestinal bleeding - Rare presentation of renal cell carcinoma

Abstract

Renal cell carcinoma (RCC) constitutes 2-3% of all adult malignancies and often diagnosed incidentally. Classical tried of RCC now rarely seen, it behaves unpredictably and having diverge range of clinical manifestation including paraneoplastic syndromes. Upper gastrointestinal (GI) bleeding due to stomach metastasis of RCC is uncommon and to the best of our knowledge, only few cases are reported in world literature and most of them were diagnosed during follow-up after complete treatment of RCC but in our case, it was the primary manifestation of disease. Our case also demonstrates the importance of imaging in undiagnosed cases of upper GI bleeding.

Metastatic gastric tumors arising from renal cell carcinoma: Clinical characteristics and outcomes of this uncommon disease

“…The reference lists of the articles identified in this manner were then manually searched to identify any additional references and articles published only in abstract form were excluded. From this search, we identified 22 cases of gastric metastases arising from RCC (1,5,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

Gastric metastasis of renal cell carcinoma 20 years after radical nephrectomy

“…[1] It is the third most frequently seen neoplasia of the urogenital system. [2] Twenty -five percent of the cases are at advanced stage, and metastasize.…”

“…[3] Renal cell carcinoma can spread through lymphatic, hematogenous, transcoelomic routes or through direct invasion. [1] It most frequently metastasizes into lungs, soft tissue, bone, liver, and central nervous system. [1] Apart from these conventional regions, metastatic lesions into the stomach are very rarely seen.…”

“…[1] It most frequently metastasizes into lungs, soft tissue, bone, liver, and central nervous system. [1] Apart from these conventional regions, metastatic lesions into the stomach are very rarely seen. [1,3] Up to now we could detect only a total of 50 cases in the literature.…”

“…[1] Apart from these conventional regions, metastatic lesions into the stomach are very rarely seen. [1,3] Up to now we could detect only a total of 50 cases in the literature. [1][2][3][4][5][6][7][8][9][10][11][12] In only 4 of these cases gastric metastases developed 20 or more years after diagnosis of renal cell carcinoma.…”