Metastatic gastric tumors arising from renal cell carcinoma: Clinical characteristics and outcomes of this uncommon disease

Namikawa, Tsutomu; Munekage, Masaya; Kitagawa, Hiroyuki; Okabayashi, Takehiro; Kobayashi, Mariko; Hanazaki, Kazuhiro

doi:10.3892/ol.2012.807

Cited by 23 publications

(31 citation statements)

References 29 publications

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“…In 2011, Eslick and Kalantar [8] reviewed the literature on GM in RCC, finding 44 cases reported since 1980. Namikawa et al [9] analyzed data from 22 case reports and found melena, anemia, and hematemesis as the most frequent signs at presentation. GM were most often single, had a polyp-like appearance and a median size of 3 cm, developing most frequently in the body of the stomach [9].…”

Section: Discussionmentioning

confidence: 99%

“…Namikawa et al [9] analyzed data from 22 case reports and found melena, anemia, and hematemesis as the most frequent signs at presentation. GM were most often single, had a polyp-like appearance and a median size of 3 cm, developing most frequently in the body of the stomach [9]. Reports on esophageal metastases (EM) in RCC are much more scant.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Renal cell cancer metastases to esophagus and stomach successfully treated with radiotherapy and pazopanib

Cabezas-Camarero¹,

Puente²,

Manzano³

et al. 2015

Anti-Cancer Drugs

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Renal cell cancer has been rarely reported as a cause of gastric or esophageal metastases. They usually present with gastrointestinal bleeding and most cases have been managed surgically or endoscopically. We report the case of a 38-year-old man with a 4-year history of metastatic renal cell carcinoma admitted to the emergency room with melena and anemia. At endoscopy, three esophageal polypoid lesions (middle and distal thirds) and a 7 cm mass in the gastric fundus were identified. Biopsy revealed esophageal mucosa infiltrated by renal cell carcinoma. Radiotherapy was administered (30 Gy in 10 fractions), followed by pazopanib, with excellent tolerance and without new bleeding episodes. Computed tomography scan showed complete disappearance of the esophageal and fundic lesions at 3 months follow-up. Twenty-four months after being initiated on pazopanib, there is no radiological evidence of disease. This is the first reported case showing complete remission of gastric and esophageal metastases after treatment with radiotherapy and pazopanib.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Renal cell cancer metastases to esophagus and stomach successfully treated with radiotherapy and pazopanib

Cabezas-Camarero¹,

Puente²,

Manzano³

et al. 2015

Anti-Cancer Drugs

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“…Furthermore, in the case of solitary gastric metastasis from a renal cell carcinoma, the patient achieved long-term survival without the occurrence of any new lesions. Previous studies have also reported that patients with solitary gastric metastasis arising from renal cell carcinoma have good outcomes following treatment compared with patients with multiple metastases (5,17).…”

Section: Discussionmentioning

confidence: 92%

“…Examination of the tumors revealed ulcerated tumors in three patients, linitis plastica lesion in two, and a protruding tumor in another two patients. In one patient, the condition was diagnosed from biopsy specimens using endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) (5).…”

Section: Resultsmentioning

confidence: 99%

Clinical presentation and treatment of gastric metastasis from other malignancies of solid organs

Namikawa¹,

Munekage²,

Ogawa³

et al. 2017

Biomedical Reports

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Abstract. The aim of the present study was to analyze the clinicopathologic features and treatment outcomes of gastric metastasis from other malignancies of solid organs. A review was conducted of patients with metastatic tumors in the stomach from other malignancies of solid organs detected endoscopically at the Department of Surgery, Kochi Medical School, from January 1991 to December 2015. Seven patients (four men and three women), with a median age of 64 years (range, 42-71 years), had metastatic gastric tumors. Median tumor size was 7.3 cm (range, 2.5-12.0 cm). The primary malignancy leading to metastatic tumors in the stomach was esophageal cancer in three patients, breast cancer in two patients, renal cell carcinoma in one patient, and ovarian cancer in one patient. Gastric metastasis presented as solitary lesions in six patients and as multiple lesions in one patient. Four patients had solitary gastric metastasis, whereas three had multiple metastases in other organs. The median tumor size was significantly smaller in patients with solitary rather than multiple metastases (4.6 vs. 12.0 cm, respectively; P=0.038). Three patients received systemic therapy and four underwent surgical resection of the metastatic tumor, and of these, only one was alive 58 months after surgery. Clinicians should be aware of the possible existence of metastatic gastric cancer, especially in breast carcinoma and esophageal cancer. Surgical resection may considerably improve patients' quality of life, and could be of benefit when there is a risk of bleeding and/or a solitary metastasis.

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“…In the last three studies and some others [9,[12][13][14][15][16], the case reported by Lamb et al [62] is repeatedly presented as a metastatic case, while in fact, it clearly describes a direct invasion of the stomach by the renal primary tumor. In the study by Namikawa et al [13], the occurrence of GM B 6.3 years after treatment of the primary, and GM of the ''protruding'' type (similar to our ''polypoid'' type), conferred a worse prognosis, with a considerably shorter median survival (5 months).…”

Section: Discussionmentioning

confidence: 92%

Gastric and esophageal metastases in renal cell carcinoma: systematic review and management options

et al. 2014

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Renal cell cancer (RCC) has been rarely reported as a cause of gastric (GM) or esophageal metastases (EM). The aim of this review was to study the clinical characteristics, management, and outcome of GM and EM in RCC. A systematic review of the literature was conducted by searching four major online databases. Sixtyeight cases were identified: 64 with GM, and 6 with EM (2 had coincident GM and EM). GM presented more often with anemia and gastrointestinal bleeding, were more frequent in the body or fundus, and used to be single. Median interval from diagnosis of RCC to GM (IGM) was 54 months (range 0-288). Cases reported after year 2004 demonstrate an increasing tendency to use endoscopic resections and to perform less aggressive surgical procedures for GM. Bleeding (p = 0.009), melena (p = 0.024), and an IGM B 54 months (p = 0.055) occurred more often in women. Both larger GM (p = 0.015) and a shorter IGM (p = 0.004) were more frequent when there were metastases in other organs. We report the largest review to date on GM and EM in RCC, and we show the increasing tendency to use less aggressive treatments for GM in the last decade. Female sex may be a risk factor for bleeding of GM. Female sex, larger GM and a shorter IGM, may be associated with a more aggressive disease in RCC. The possible treatment options for these rare entities are also discussed.

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Metastatic gastric tumors arising from renal cell carcinoma: Clinical characteristics and outcomes of this uncommon disease

Cited by 23 publications

References 29 publications

Renal cell cancer metastases to esophagus and stomach successfully treated with radiotherapy and pazopanib

Renal cell cancer metastases to esophagus and stomach successfully treated with radiotherapy and pazopanib

Clinical presentation and treatment of gastric metastasis from other malignancies of solid organs

Gastric and esophageal metastases in renal cell carcinoma: systematic review and management options

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