Gastric metastasis of renal cell carcinoma 20 years after radical nephrectomy

Abstract

Renal cell carcinomas account for 2-3% of malignant neoplasms in adults. The lung, soft tissues and bone represent the most frequent sites of distant metastasis in renal cell carcinoma. Gastric metastasis is rare. Our case was a 72-year-old man with complaints of fatigue and loss of appetite. In history, he had unergone radical nephrectomy due to renal cell carcinoma in 1993. A polypoid lesion was observed in upper gastrointestinal endoscopy. Histopathology of gastric biopsy specimen was reported as renal cell carcinoma. In English literature, there are 50 cases diagnosed as gastric metastasis from renal cell carcinoma. To date, there are only 4 cases with extremely late gastric metastasis of renal cell carcinoma. Herein, we present a rare case which underwent radical nephrectomy due to renal cell carcinoma and found to have gastric metastasis at 20. year of his follow-up.

Are gastric metastases of renal cell carcinoma really rare? A case report and systematic review of the literature

“…Gastric metastasis of RCC has been described [ [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] ] and it is associated with poor outcome, with only a third of patients being alive after one year [ 23 ]. Usually, gastric metastases are asymptomatic, single and located in the gastric body or fundus [ 23 , 33 ].…”

Application of 18F Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Monitoring Gastric Metastasis and Cancer Thrombi from Renal Cell Carcinoma

“…We identified 73 cases of RCC with gastric metastasis from literature reviews. Including the patient treated in our hospital, there were 5 cases of RCC with simultaneous solitary gastric metastasis [4,[16][17][18][19] (Table 1), 4 cases with gastric and multiple-site metastases [20][21][22][23] (Table 2), 21 cases with solitary metachronous gastric metastasis [16,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] (Table 3), and 44 cases with metachronous gastric and multiple-site metastases [32, (Table 4).…”

Renal Cell Carcinoma with Gastric and Paratracheal Metastases

“…Renal cell carcinoma (RCC) has been known to metastasize to almost all organ systems [1], however gastric metastasis is rare, with 50 cases reported in the literature to date [2]. There are also few reports of Para-tracheal RCC metastases.…”