Treatment of gastric metastases from renal cell carcinoma with endoscopic therapy

Herculano, Rita; Isabel, Alves; Chapim, Iolanda; Hann, Alexander; Costa, Pedro Fidalgo e; Carvalho, Liliana; Monteiro, Lucília; Santos, Sofia; Matos, Leopoldo

doi:10.1007/s12328-014-0470-x

Cited by 11 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastric metastases from RCC are exceedingly rare [ 5 , 6 ]. Pollheimer et al [ 5 ] reported 5 patients who developed gastric metastases from an Austrian database of 2,082 RCC patients.…”

Section: Discussionmentioning

confidence: 99%

“…Most RCC gastric metastases are located in the gastric body and fundus. Single tumors predominate over multiple tumors [ 6 ]. Histologically, these metastases are situated in the submucosa [ 3 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Uncommon metastatic sites, including the gastrointestinal tract [ 2 – 4 ], have also been reported. Gastric metastasis from RCC is rare [ 5 , 6 ]. Gastric metastases are typically asymptomatic, single, and located in the gastric body or fundus [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Gastric metastasis from RCC is rare [ 5 , 6 ]. Gastric metastases are typically asymptomatic, single, and located in the gastric body or fundus [ 5 , 6 ]. If they are symptomatic, then gastrointestinal bleeding and anemia are the most common presentations [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Gastric Metastasis from Renal Cell Carcinoma, Clear Cell Type, Presenting with Gastrointestinal Bleeding

Ghanimeh

Qasrawi

Abughanimeh

et al. 2017

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

Renal cell carcinoma (RCC) accounts for 80–85% of all primary renal neoplasms. Although RCC can metastasize to any organ, gastric metastases from RCC are exceedingly rare. A 67-year-old male presented with melena and acute blood loss anemia. The patient had a history of RCC that had been treated with a radical nephrectomy. He had a recent myocardial infarction and was receiving double antiplatelet therapy. After hemodynamic stabilization, esophagogastroduodenoscopy showed a polypoid mass in the gastric fundus. The mass was excised. Histological and immunohistochemical evaluation were consistent with clear cell RCC. The polypoid lesion is consistent with a late solitary metastasis.

show abstract

“…Gastric metastases from RCC are exceedingly rare [ 5 , 6 ]. Pollheimer et al [ 5 ] reported 5 patients who developed gastric metastases from an Austrian database of 2,082 RCC patients.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gastric Metastasis from Renal Cell Carcinoma, Clear Cell Type, Presenting with Gastrointestinal Bleeding

Ghanimeh

Qasrawi

Abughanimeh

et al. 2017

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

show abstract

“…Its reported primary tumor types are breast cancer (27%), lung cancer (23%), RCC (7.6%), and malignant melanoma (7%) [5,6]. Among the various possible metastatic sites from RCC, the stomach has only rarely been reported [8][9][10][11][12][13][14]. Cabezas-Camerero et al reviewed 62 cases of gastric metastases from renal cell carcinoma [8].…”

Section: Discussionmentioning

confidence: 99%

A case of gastric metastasis from renal cell cancer during the sequential targeted therapy

et al. 2017

View full text Add to dashboard Cite

Historically, gastric metastasis from renal cell cancer (RCC) has been extremely rare. As RCC is now being treated with various agents of targeted therapy, however, the rate of unusual visceral metastases might increase as outcomes improve and follow-up periods grow longer. Here we present a valuable case of gastric metastasis from RCC detected in a routine CT scan during sequential targeted therapy. A 73-year-old man was referred to our hospital, presenting with left renal cell cancer with multiple lung metastases at stage cT1bN0M1. He received first-line targeted therapy consisting of sunitinib and subsequently underwent left radical nephrectomy. He then underwent sequential therapy consisting of interferon-alpha, sunitinib, everolimus, and axitinib for multiple lung metastases. Five years after nephrectomy, a follow-up computed tomography scan revealed a 2.2 × 1.6 cm mass in the stomach without any symptoms. Gastrointestinal endoscopy disclosed a polypoid lesion at the gastric fundus. Endoscopic submucosal resection was performed. Microscopic diagnosis revealed gastric metastasis from RCC. As various new therapeutic agents increase survival periods for metastatic RCC patients in this era of targeted therapy, clinicians must watch for metastasis in the stomach, though this was formerly a rare event.

show abstract

Gastric metastasis from renal cell carcinoma 12 years after right radical nephrectomy

Chu

Peng

Chang

et al. 2019

Adv in Digestive Medicine

View full text Add to dashboard Cite

Gastric metastasis from renal cell carcinoma (RCC) after nephrectomy is unusual, and few cases have been reported, with a mean duration of 6.9 years from the diagnosis of RCC to gastric metastasis. We report a case of gastrointestinal bleeding in a patient who received right radical nephrectomy for RCC 12 years ago. Esophagogastroduodenoscopy found an ulcerative mass, and metastatic RCC was finally diagnosed via histopathological examination and immunohistochemistry staining. RCC usually metastasizes to the lung, lymph nodes, and bone. It rarely metastasizes to the stomach, and there is no specific symptom despite gastric metastasis. Early detection of gastric metastasis should be conducted due to a lack of effective systemic therapy for RCC. In conclusion, endoscopic survey is recommended for patients of RCC with any suspicious symptoms, including epigastric pain, dyspepsia, decreasing appetite, hematemesis, melena, or anemia.

show abstract

Treatment of gastric metastases from renal cell carcinoma with endoscopic therapy

Abstract: Gastric metastases of RCC are rare but should be considered even many years after diagnosis and treatment of RCC, particularly in patients with gastrointestinal symptoms.

Cited by 11 publications

References 30 publications

Gastric Metastasis from Renal Cell Carcinoma, Clear Cell Type, Presenting with Gastrointestinal Bleeding

Gastric Metastasis from Renal Cell Carcinoma, Clear Cell Type, Presenting with Gastrointestinal Bleeding

A case of gastric metastasis from renal cell cancer during the sequential targeted therapy

Gastric metastasis from renal cell carcinoma 12 years after right radical nephrectomy

Contact Info

Product

Resources

About