Umbelliferone – An antioxidant isolated from Acacia nilotica (L.) Willd. Ex. Del.

Singh, Rajbir; Singh, Bikram; Singh, Sukhpreet; Kumar, Neeraj; Kumar, Subodh; Arora, Saroj

doi:10.1016/j.foodchem.2009.11.022

Cited by 115 publications

(56 citation statements)

References 22 publications

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“…The active dichloromethane extracts were subjected to column chromatography over silica gel and sephadex LH-20. As the result, eleven coumarins osthole (1) (Sajjadi et al, 2009), imperatorin (2) (Muller et al, 2004), bergapten (3) (Stevenson et al, 2003), prantschimgin (4) (Sajjadi et al, 2015), grandivitinol (5) (Abyshe et al, 1977), suberosin (6) (Tabanca et al, 2016), xanthotoxin (7) (Stevenson et al, 2003), felamidin (8) (Kilic et al, 2006), marmesin (9) (Abreu et al, 2010), umbelliferone (10) (Singh et al, 2010), ulopterol (11) (Doganca et al, 1979) and a sterol mixture consisted of stigmasterol (12), β-sitosterol (13) (Woldeyes et al, 2012) (Figure 1) were isolated and identified.…”

Section: Resultsmentioning

confidence: 99%

α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots

Karakaya

Özbek

Gözcü

et al. 2018

Bangladesh J Pharmacol

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Eleven coumarins named osthole (1), imperatorin (2), bergapten (3), prantschimgin (4), grandivitinol (5), suberosin (6), xanthotoxin (7), felamidin (8), marmesin (9), umbelliferone (10), ulopterol (11), and a sterol mixture consisted of stigmasterol (12), β-sitosterol (13) were isolated from the roots of Ferulago blancheana, F. pachyloba and F. trachycarpa through in vitro bioassay-guided fractionation processes. The extracts and bioactive compounds were evaluated for their α-amylase and α-glucosidase activities. Among the tested compounds, felamidin and suberosin showed significant α-glucosidase inhibitory activity with IC50 values of 0.4 and 0.9 mg/mL, respectively, when compared to the reference standard acarbose (IC50 = 4.9 mg/mL). Grandivitinol (IC50 = 20.0 mg/mL) had the lowest inhibitory effect. On the other hand, none of the tested extracts were found to be active on α-amylase inhibition. This is the first report on isolation, characterization of the bioactive compounds and evaluation the α-amylase and α-glucosidase inhibitory activities of these species.Video Clip of Methodology:8 min 26 sec: <a href="https://www.youtube.com/v/x0gakPjgXmc">Full Screen</a> <a href="https://www.youtube.com/watch?v=x0gakPjgXmc">Alternate</a>

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Section: Resultsmentioning

confidence: 99%

α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots

Karakaya

Özbek

Gözcü

et al. 2018

Bangladesh J Pharmacol

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“…Similarly, gallic acid and catechin showed protective effect against N-nitrosodiethylamine-induced hepatocarcinogenesis (Brahma et al, 2009). Umbelliferone is also reported as potential scavenger of free radicals which is present in bark and leaves of A.nilotica (Rajbir et al, 2010). Recently, a report indicates that apigenin can act as potential chemopreventing agent due to induction of leukemia cell cycle arrest.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a report indicates that apigenin can act as potential chemopreventing agent due to induction of leukemia cell cycle arrest. Apigenin inhibited phosphoinositide 3-kinase/protein kinase B (PI3K/ PKB) pathway in HL60 and induced caspase-dependent apoptosis (Rajbir et al, 2010). Androstene also exhibits dose dependent anti-inflammatory property against TPA (12-O-tetradecanoylphorbol-13-acetate) induced mouse ear edema (Chaubal et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…The published reports of various biological activities of Acacia species include hypoglycemic, anti-inflammatory, antitumor (Lam and Ng, 2010), antifungal (Lopes et al, 2009), antiplatelet aggregation, spasmogenic and vasoconstrictor, antihypertensive, anti-hepatitis C virus (Lee et al, 2011) antioxidant potential , wound healing (Tung et al, 2008), antinociceptive activity (Dongmo et al, 2005), chemopreventive and antimutagenic , anthelmintic activity (Bachaya et al, 2009). Several bioactive agents have been identified from the various species of acacia which includes androstene steroid, gallic acid, ellagic acid, isoquercitin, kaempferol, naringenin, rutin, lupane, niloticane, umbelliferone and catechin (Mutai et al, 2004;Eldeen et al, 2005;Chaubal et al, 2006;Singh et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…So far several biologically active compounds include umbelliferone, gallic acid, niloticane, catechin, kaempferol, rutin, apigenin and two steroids include androstene and β-sitoterol were isolated from different parts of A.nilotica (Brahma et al, 2009). Numerous studies in A.nilotica showed interesting biological activities (Dongmo et al, 2005;Meena et al, 2006;Tung et al, 2008;Bachaya et al, 2009;Lopes et al, 2009;Lam and Ng, (2010); Singh et al, 2010;Lee et al, 2011) however, no antitumor activity against DAL induced solid and ascitic tumor has been reported. Therefore based on the ethno medical claims, the present study was planned to explore the possible in vivo antitumor activity of aerial parts of A.nilotica against DAL induced solid and ascitic tumor in BALB/c mice.…”

Section: Introductionmentioning

confidence: 99%

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Anticancer Activity of Acacia nilotica (L.) Wild. Ex. Delile Subsp. indica Against Dalton's Ascitic Lymphoma Induced Solid and Ascitic Tumor Model

Sakthivel¹,

Kannan²,

Angeline³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Effect of Acacia nilotica Against Dalton's Ascitic Lymphoma ModelAsian Pacific J Cancer Prev, 13, 3989-3995 IntroductionOver the past decade, Cancer is the leading cause of death worldwide and it is characterized by uncontrolled growth and spread of abnormal cells. World Health Organization (WHO) reported that there are 7.6 million deaths in 2008 and it is estimated up to 13.1 million deaths in 2030 (Merel et al., 2012). Treatment of cancer varies according to each type, has been facing large number of problems. Several ways in the treatment of cancer have been developed. Currently cancer is treated using surgery, radiation, and chemotherapy which are associated with severe side effects (Garcia et al., 2001;Edy et al., 2012). Even a large number of tumors are scantily responsive to cancer therapeutic drugs and radiotherapy. Identification and development of natural products used for cancer prevention have attracted a lot of attention globally. Herbal extracts with their proven potential and less side effects in therapeutics has replaced the synthetically derived drugs in modern allopathic medication system (Sakthivel and Guruvayoorappan, 2012). Traditionally used large number of medicinal plants and plant products has become the potential source of antitumor agents. Traditional healers of different regions in India particularly Chhattisgarh used Acacia species for treatment of various cancer types of mouth, bone and skin (Kalaivani and Mathew, 2010

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Secondary Metabolites of Medicinal Plants

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Umbelliferone – An antioxidant isolated from Acacia nilotica (L.) Willd. Ex. Del.

Cited by 115 publications

References 22 publications

α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots

α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots

Anticancer Activity of Acacia nilotica (L.) Wild. Ex. Delile Subsp. indica Against Dalton's Ascitic Lymphoma Induced Solid and Ascitic Tumor Model

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