Anticancer Activity of Acacia nilotica (L.) Wild. Ex. Delile Subsp. indica Against Dalton's Ascitic Lymphoma Induced Solid and Ascitic Tumor Model

Abstract

Effect of Acacia nilotica Against Dalton's Ascitic Lymphoma ModelAsian Pacific J Cancer Prev, 13, 3989-3995 IntroductionOver the past decade, Cancer is the leading cause of death worldwide and it is characterized by uncontrolled growth and spread of abnormal cells. World Health Organization (WHO) reported that there are 7.6 million deaths in 2008 and it is estimated up to 13.1 million deaths in 2030 (Merel et al., 2012). Treatment of cancer varies according to each type, has been facing large number of problems. Several ways in the treatment of cancer have been developed. Currently cancer is treated using surgery, radiation, and chemotherapy which are associated with severe side effects (Garcia et al., 2001;Edy et al., 2012). Even a large number of tumors are scantily responsive to cancer therapeutic drugs and radiotherapy. Identification and development of natural products used for cancer prevention have attracted a lot of attention globally. Herbal extracts with their proven potential and less side effects in therapeutics has replaced the synthetically derived drugs in modern allopathic medication system (Sakthivel and Guruvayoorappan, 2012). Traditionally used large number of medicinal plants and plant products has become the potential source of antitumor agents. Traditional healers of different regions in India particularly Chhattisgarh used Acacia species for treatment of various cancer types of mouth, bone and skin (Kalaivani and Mathew, 2010

Ethanol but not Aqueous Extracts of Tubers of Sauromatum Giganteum(Engl.) Cusimano and Hett Inhibit Cancer Cell Proliferation

“…The solubility and acute toxicity of extract were determined, the max solubility of ethanol extract and aqueous extract was 15 mg/mL and 20 mg/mL, respectively. The aim of the "Acute toxicity study in vivo" is that determining the median lethal dose (LD50) (Zhang et al, 2014) or the largest drug concentration and providing the basis for dosage regimen in the follow-up research (Sakthivel et al, 2012). The result showed that no deaths or adverse effects were detected during the 24 hour observation period in mice treated with up to the max administration dose of ethanol extract (1200 mg/kg.bw=15mg/ mL×0.8mL/20g·bw×twice/day×50) or aqueous extract (1600 mg/kg.bw=20mg/mL×0.8mL/20g·bw×twice/ day×50).…”

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

“…Presently, some herbal medicines (phytopharmaceuticals) with better effectiveness and minimal side-effects have been used in modern medicine as replacements for some synthetically derived molecules (Kalaivani et al, 2014). Previous studies from our laboratories showed that agents derived from Rhizopora apiculata, Thespesia populnea, and Acacia nilotica imparted strong anti-inflammatory, -oxidant and -cancer effects in test systems (Denish & Guruvayoorappan, 2013;Sakthivel et al, 2012;Vinod & Guruvayrooppan, 2012).…”

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“…Gamma-sitosterol of A. nilotica exhibited potential anticancer activity through the growth inhibition, cell cycle arrest and the apoptosis on MCF-7 and A549 cells 5 . The aerial parts of methanolic extract of Acacia nilotica have anticancer activity against Dalton's ascetic lymphoma induced solid and ascetic tumor model 6 . …”