α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots

Karakaya, Songül; Özbek, Hikmet; Gözcü, Sefa; Güvenalp, Zühal; Yuca, Hafize; Duman, Hayrí; Kazaz, Cavit; Kılıç, Ceyda Sibel

doi:10.3329/bjp.v13i1.33668

Cited by 10 publications

(2 citation statements)

References 25 publications

(26 reference statements)

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“…This might be speculated that the AGIs present in TGK are more soluble in nonpolar organic solvent. In previous researches, strong α‐glucosidase inhibition of DCF from extracts have been reported in extracts of Ferulago bracteata roots, blancheana , F. pachyloba , and F. trachycarpa (Karakaya, Gözcü, et al, ; Karakaya, Özbek, et al, ).…”

Section: Resultsmentioning

confidence: 96%

Antioxidant, metabolic enzymes inhibitory ability of Torreya grandis kernels, and phytochemical profiling identified by HPLC‐QTOF‐MS/MS

Zhu

Zhang

et al. 2019

J Food Biochem

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In this study, the antioxidant activities, α‐glucosidase and tyrosinase inhibitory ability of Torreya grandis kernels (TGK) were performed. Samples were extracted with various polarity of ethanol, and the major phytochemical profile was characterized. The results showed that 70% of ethanol extract gave the richest phenolics and flavonoids. The strongest DPPH· and ABTS·+ scavenging ability, as well as the best inhibition on tyrosinase and α‐glucosidase was also detected on 70% of ethanol extract. Among the fractions of 70% of ethanol extract, the ethyl acetate fraction (EAF) owned the highest phenolics, flavonoids, and the best DPPH· and ABTS·+ scavenging ability, and tyrosinase inhibition. Unexpectedly, the dichloromethane fraction possessed the strongest inhibition on α‐glucosidase, which was much greater than that of acarbose. HPLC‐QTOF‐MS/MS analysis result to the characterization of 19 compounds from EAF. The results implied that TGK can be a potential source of natural antioxidants, α‐glucosidase and tyrosinase inhibitors. Practical applicationsThe kernels of T. grandis are one of the precious nuts in the world, and the extracts were advertised to show a variety of biological activities and pharmacological effects. However, researches on the phytochemical constituents and bioactivities are fewer. In this study, TGK was found to show good potency in antioxidant, α‐glucosidase and tyrosinase inhibitory activities. The 70% ethanol is the best solvent for extracting above mentioned active components, and ethyl acetate can be the suitable enriching solvent. In addition, the predominant phytochemical compounds in EAF were characterized. Therefore, this research can help to the performance of further research and application of TGK in functional products.

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Section: Resultsmentioning

confidence: 96%

Antioxidant, metabolic enzymes inhibitory ability of Torreya grandis kernels, and phytochemical profiling identified by HPLC‐QTOF‐MS/MS

Zhu

Zhang

et al. 2019

J Food Biochem

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“…3 In traditional medicine, they have been used in carminative, peptic, sedative, aphrodisiac, vermifuge, immunostimulant, flavor, digestive, tonic, germicidal, and antibronchitis applications, as well as against ulceration, nuisance, snakebite, hemorrhoids, and splenetic illnesses. 4 Coumarins, 5,6 sesquiterpenes, 6 strerol, 7,8 and flavonoids 9,10 have previously been found in Ferulago species.…”

Section: Introductionmentioning

confidence: 89%

Phytochemical analysis and biological evaluation of Ferulago setifolia K. Koch

Gözcü,

Akşit,

Şimşek

et al. 2023

J Sci Food Agric

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BackgroundFerulago setifolia K. Koch (Apiaceae) has been the subject of this study, aiming to comprehensively determine its phenolic fingerprint and evaluate its various biological activities. The LC‐MS/MS analysis of the 70% methanol extract of Ferulago setifolia (FS) has revealed the presence of 23 phytochemicals. Among them, chlorogenic acid, quinic acid, kaempferol‐3‐O‐glucoside, and quercetin‐3‐O‐glucoside were identified as the major phenolics in the extract.ResultsThe biological screening included examinations of antioxidant, antibacterial, antiproliferative, and cytotoxic activities. The FS extract displayed moderate DPPH radical scavenging and ferric‐reducing capacity, indicating moderate antioxidant activity. Furthermore, FS exhibited significant antiproliferative effects on cancer cells while showing low cytotoxicity on normal cells. The antibacterial activity findings revealed that FS demonstrated potent activity against Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus, and Escherichia coli.ConclusionThe findings of this study suggest that the methanolic extract of FS holds promise as a potential source of biologically active compounds. It can be utilized for the development of pharmaceutical formulations, thanks to its significant antiproliferative and antibacterial activities. Additionally, FS can serve as a valuable source of chlorogenic acid for industrial applications.This article is protected by copyright. All rights reserved.

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Phytochemical and Biological Characteristics of Apiaceae Species from Turkey

Özek,

Yur

2023

Medicinal and Aromatic Plants of the World

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α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots

Cited by 10 publications

References 25 publications

Antioxidant, metabolic enzymes inhibitory ability of Torreya grandis kernels, and phytochemical profiling identified by HPLC‐QTOF‐MS/MS

Antioxidant, metabolic enzymes inhibitory ability of Torreya grandis kernels, and phytochemical profiling identified by HPLC‐QTOF‐MS/MS

Phytochemical analysis and biological evaluation of Ferulago setifolia K. Koch

Phytochemical and Biological Characteristics of Apiaceae Species from Turkey

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