Two New Triterpene Glycosides from the Vietnamese Sea CucumberHolothuria scabra

Abstract

Two new triterpene glycosides, namely holothurin A3 (1) and A4 (2) were isolated from the methanol extract of the sea cucumber, Holothuria scabra, with their structures elucidated from the spectroscopic evidence (1D NMR, 2D NMR, ESI-MS and HRESI-MS). Compounds 1 and 2 were found to be strongly cytotoxic to both cancer cell lines, KB and Hep-G2, with 50% inhibitory concentrations (IC50) of 0.87 and 0.32 microg/mL (for compound 1) and of 1.12 and 0.57 microg/mL (for compound 2), respectively.

Antifungal effect of Sticophus hermanii and Holothuria atra extract and its cytotoxicity on gingiva-derived mesenchymal stem cell

“…Sea cucumbers, informally named as bêche-de-mer, or gamat, have long been used for food and folk medicine in the communities of Asia and Middle East. [1][2][3][4][5][6] Marine biota is the source of structurally unique natural products that are mainly accumulated in living organisms, not just as food consumption and industrial need but later has been known to have biomedical properties. Therapeutic properties and medicinal benefits of sea cucumbers can be linked to the presence of a wide array of bioactives especially triterpene glycosides (saponins), chondroitin sulfates, glycosaminoglycan (GAGs), sulfated polysaccharides, sterols (glycosides and sulfates), phenolics, cerberosides, lectins, peptides, glycoprotein, glycosphingolipids and essential fatty acids.…”

Cosmeceuticals Properties of Sea Cucumbers: Prospects and Trends

“…Saponins are reported as the major bioactive compound in many effective traditional Chinese and Indian herbal medicines [58]. They play an important role in chemical defence and possess a wide spectrum of pharmacological activities [59][60][61][62][63][64][65][66][67][68]. The majority of sea cucumber saponins, generally known as Holothurins, are usually triterpene glycosides, belonging to the holostane type group rather than non-holostane [62].…”

“…They play an important role in chemical defence and possess a wide spectrum of pharmacological activities [59][60][61][62][63][64][65][66][67][68]. The majority of sea cucumber saponins, generally known as Holothurins, are usually triterpene glycosides, belonging to the holostane type group rather than non-holostane [62]. The structural features of these compounds are quite comparable to those of the bioactives from ganoderma, ginseng, and other medicinally-popular tonic herbs [63].…”

IDENTIFICATION OF SECONDARY METABOLITES COMPOUNDS, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES ON THE METHANOL EXTRACT OF SEA CUCUMBER Stichopus hermanii

“…Beberapa senyawa bioaktif yang telah berhasil diisolasi dari teripang antara lain 24-dehydroholothurin A (Kobayashi et al, 1991;Jawahar et al, 2002), holothurin A (Dang et al, 2007;Jawahar et al, 2002), holothurin B (Elyakov et al, 1973;Jawahar et al, 2002); hillaside A dan B (Wu et al, 2007); okhotensis B1-B3 (Silchenko et al, 2008). marmoratoside A, alpha-hydroxy impatienside A, marmoratoside B, dan 25-acetoxy bivittoside D (Yuan et al, 2009).…”