Antifungal effect of Sticophus hermanii and Holothuria atra extract and its cytotoxicity on gingiva-derived mesenchymal stem cell

Parisihni, Kristanti; Revianti, Syamsulina

doi:10.20473/j.djmkg.v46.i4.p218-223

Cited by 8 publications

(7 citation statements)

References 15 publications

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“…H. atra extract were not cytotoxic togingiva-derived mesenchymal stem cell in the concentration of ≤ 0.5%; suggesting the extract safety and can be develop for further phase of clinical trial. 31 The use of human cells could increase the correlation between safety studies and clinical trials, an important benefit since conventional animal models of toxicity are not always predictive of human responses. Extract of H. atra were also effective against the Malassezia furfur fungus that causes tinea versicolor.…”

Section: Chemical Composition Of Various Sea Cucumbersmentioning

confidence: 99%

Medicinal and health benefit effects of functional sea cucumbers

Pangestuti

Arifin

2018

Journal of Traditional and Complementary Medicine

184

118

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Sea cucumbers have long been used as food and traditional medicine in Asian countries with Stichopus hermanni, Thelenota ananas, Thelenota anax, Holothuria fuccogilva, and Actinopyga mauritiana as most highly-valued species. These organisms are potential source of high value-added compounds with therapeutic properties such as triterpene glycosides, carotenoids, bioactive peptides, vitamins, minerals, fatty acids, collagens, gelatins, chondroitin sulfates, amino acids. In the recent years, health benefit effects of sea cucumbers have been validated through scientific research and have shown medicinal value such as wound healing, neuroprotective, antitumor, anticoagulant, antimicrobial, and antioxidant. These functional materials lead to potential development in various foods and biomedicine industries. In this review, we have presented a general view of major medicinal and health benefit effects of functional sea cucumbers from Asia region. The structural significance and the potential application of sea cucumber-derived functional materials as well as their nutritional value are also discussed.

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Section: Chemical Composition Of Various Sea Cucumbersmentioning

confidence: 99%

Medicinal and health benefit effects of functional sea cucumbers

Pangestuti

Arifin

2018

Journal of Traditional and Complementary Medicine

184

118

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“…The body wall of sea cucumber contains polysaccharides consisting of fucan sulfate and Fucosylated Chondroitin Sulfates (FuCS), which have pharmacological activity as anticoagulants and antithrombotics (31,33) . Phytochemical test of antifungal activity of H. atra extract with positive ethyl acetate solvent contains triterpene glycoside compounds that can be used as antifungals (34)(35)(36) . Phenolic compounds and alkaloids in the internal organs of H. atra can also act as antioxidants.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Study: Antimalarial Activity of Rivet Sea Cucumber Extract (Holothuria atra) With Ethyl Acetate Solvent Against Plasmodium falciparum

Utami

Febrianti²

2022

WMJ

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Abstract Indonesia is experiencing a decreased cure rate of malaria caused by the species Plasmodium falciparum. Alternative medicine, in this case, uses marine biota, namely lollyfish (Holothuria atra), which has a lot of active compound content; the purpose uses the biota because many reports that there is a failure of malaria treatment therapy due to Artemisinin-based Combination Therapy (ACT) resistance. The purpose of this study was to find out the antimalarial activity of Holothuria atra extract with ethyl acetate solvent at dose 0.01; 0.1; 1; 10; and 100 Ug/ml against Plasmodium falciparum in vitro. Extract lollyfish using the maceration method. The lollyfish powder will be dissolved with ethyl acetate solvent for 24 hours. Antimalarial activity testing is measured through 4 parameters, namely the measurement of parasitemia rates, % parasite growth, % inhibitory rate, and IC50. Antimalarial activity with ethyl acetate solvent belongs to a very active category with an IC50 value of 1.52 µg/mL. These results can kill the P. falciparum parasite with a percentage that reaches 0%. A decrease in the percentage of growth occurs when the dose given is too low so that the parasite can grow and survive. The result of higher concentrations of extracts will have a higher percentage of resistance to the growth of parasites. The potential for antimalarial activity in lollyfish extract is influenced by the presence of active content such as alkaloids, flavonoids, catechins, and pyrogallol owned by marine biota animals. This study suggests that lollyfish (H. atra) can be developed as an alternative treatment for malaria. Keywords: Holothuria atra, antimalarial, Plasmodium falciparum, in vitro

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“…Numerous research has revealed that golden gamat contains biological activities such as wound healing, pain relief, antibacterial, antifungal, antioxidant, cytotoxic, and anticancer effects. [4], [6], [7]. S.hermanni's antiplasmodial effect has never been investigated.…”

Section: Introductionmentioning

confidence: 99%

High Antiplasmodial Activity of Golden Gamat (S.hermanni) Extract Through In Vitro Study

Utami

Yudho

2021

EJBIO

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S.hermanni is a marine biota that contains active components that are anti-fungal, anti-bacterial, antioxidant, anti-inflammatory, and anti-cancer. The research focused on examining the antiplasmodial activity of an ethanol extract of S. hermanni on the proliferation of P. falciparum in vitro. The total sample size was 30 mediums, which included: (G1). No extract or chloroquine administration in the P.falciparum medium (G2). Chloroquine treatment administration on P. falciparum medium (G3). P. falciparum medium with S. hermanni extract. Parasitaemia, growth percentage, inhibitory rate, and IC50 were among the parameters evaluated. Administration of extract serial doses succeeds in reducing the percentage of parasite growth and parasitemia levels. G3 demonstrated an inhibitory rate of 88.51 % with a dose of 100 µg/ml and an IC50 of 2.86 µg/ml, indicating high antimalarial activity, although chloroquine had greater antimalarial activity than S. hermanni extract. In vitro studies on S hermanni, ethanol extract indicated that it contains bioactive components and can be an effective antiplasmodial agent.

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Antifungal effect of Sticophus hermanii and Holothuria atra extract and its cytotoxicity on gingiva-derived mesenchymal stem cell

Cited by 8 publications

References 15 publications

Medicinal and health benefit effects of functional sea cucumbers

Medicinal and health benefit effects of functional sea cucumbers

In Vitro Study: Antimalarial Activity of Rivet Sea Cucumber Extract (Holothuria atra) With Ethyl Acetate Solvent Against Plasmodium falciparum

High Antiplasmodial Activity of Golden Gamat (S.hermanni) Extract Through In Vitro Study

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