Two New Terpenoids from Endophytic Fungus Periconia sp. F-31

Ge, Hanlin; Zhang, Dewu; Li, Li; Xie, Dan; Zou, Jianhua; Si, Youhui; Dai, Jungui

doi:10.1248/cpb.59.1541

Cited by 28 publications

(24 citation statements)

References 14 publications

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“…Soft, curved spines cover the leathery skin of the fruits, each of which may contain 55-170 black seeds distributed in a creamy white flesh with a characteristic aroma and flavor [11,17]. All portions (leaves [18][19][20][21][22][23], pericarp [24][25][26] fruits [7,27,28], seeds [28,29], and roots [30]. The roots A. muricata has been used in traditional medicine, while the most widely used in the preparations of traditional medicinal decoctions are stem barks, roots, seeds, and leaves [31,32].…”

Section: Taxonomy Ecology and Physiology Of A Muricatamentioning

confidence: 99%

Review of Phytochemical and Medical Applications of Annona Muricata Fruits

2020

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Cancer disease is increasing annually worldwide, creating some concerns regarding the efficacy of the present treatment options. This has caused patients to seek alternatives to complement the chemotherapy, radiotherapy, and surgery. Annona muricata (family annonaceae) is a medicinal plant and is a fruit tree with a long history of traditional use. Annona muricata contains significant anticancer agents which called acetogenins play an important role in several cancer types. Annona Muricate has specific bioactive constituents responsible for the major anticancer, antioxidant, antimicrobial, anti-inflammatory and other health benefits of graviola include different classes of annonaceous acetogenins (metabolites and products of the polyketide pathway), alkaloids, flavonoids, sterols, and others. This review focuses on the phytochemistry, biological activities, medicinal are used as anti-cancer and antibiotic, also focuses on the mechanisms of action for the fruit extracts and acetogenins, in order to stimulate additional studies on the fruit pulp used for human consumption.

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Section: Taxonomy Ecology and Physiology Of A Muricatamentioning

confidence: 99%

Review of Phytochemical and Medical Applications of Annona Muricata Fruits

2020

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“…Graviola-derived compounds have been well correlated with a variety of anti-cancer effects that include cytotoxicity, 20,21 induction of apoptosis, 22 necrosis, 23 and inhibition of proliferation 24,25 on a variety of cancer cell lines, including breast, 26 prostate, 25 colorectal, 24 lung, 21 leukemia, 27 renal, 28 pancreatic, 20 hepatic, 29 oral, 30 melanoma, 31 cervical, 32 and ovarian cancers. 33,34 The major bioactive components that have been extracted from various graviola parts are known as annonaceous acetogenins. These are derivatives of long-chain (C32 or C34) fatty acids derived from the polyketide pathway.…”

Section: Ge-mud Impact Assessmentmentioning

confidence: 99%

“…The active isolates of graviola leaves also contain a class of compounds known as terpenoids. 33,44 These can inhibit the cell cycle at the G2/M phase of mitosis, through inhibiting spindle formation. Additionally, terpenoids can trigger apoptosis through inhibition of the enzyme topoisomerase.…”

Section: Gfe-a > Gle-a > Gle-k > Gse-amentioning

confidence: 99%

The graviola impact on human astroglioma cells: functional significance of MUDENG

et al. 2019

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“…A. muricata have been studied for the bioactive natural products produced by its endophytic fungal populations. [14][15][16][17][18][19][20][21][22][23] 14,15,17 and sesquiterpenes: periconianones C-K. 19 Secondary metabolites of endophytic fungi of A. muricata showed anticancer activities. 22,23 Periconiasins A and B showed significant cytotoxicity against human colon cancer cells (HCT-8).…”

Section: Introductionmentioning

confidence: 99%