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Cancer disease is increasing annually worldwide, creating some concerns regarding the efficacy of the present treatment options. This has caused patients to seek alternatives to complement the chemotherapy, radiotherapy, and surgery. Annona muricata (family annonaceae) is a medicinal plant and is a fruit tree with a long history of traditional use. Annona muricata contains significant anticancer agents which called acetogenins play an important role in several cancer types. Annona Muricate has specific bioactive constituents responsible for the major anticancer, antioxidant, antimicrobial, anti-inflammatory and other health benefits of graviola include different classes of annonaceous acetogenins (metabolites and products of the polyketide pathway), alkaloids, flavonoids, sterols, and others. This review focuses on the phytochemistry, biological activities, medicinal are used as anti-cancer and antibiotic, also focuses on the mechanisms of action for the fruit extracts and acetogenins, in order to stimulate additional studies on the fruit pulp used for human consumption.

Gold nanoparticles (AuNPs) have received considerable attention recently because of their chemical properties and potential applications in the medical field.Monodispersed AuNPs in this paper are successfully synthesized by using some stabilized ligands including 3,5-dinitrobenzoic acid (DNBA) and sodium acetate (SA) dispersible in aqueous media, where NaBH4 was used as a reducing agent to reduce KAuCl4 from Au (III) to Au (0).The synthesized AuNPs are characterized by using UV–Vis spectroscopy to evaluate their surface plasmon resonance (SPR) absorption in a wavelength range of 500–650 nm. The size and morphology of AuNPs were determined by transmission electron microscopy (TEM) and dynamic light scattering (DLS), where the results displayed that AuNPs with a strong SPR peak around 530 nm and 536 nm with an average size of 10 ± 1.2 nm and 14.0 ± 0.9 nm at the initial time for both DNBA-AuNP and SA-AuNP respectively. The synthesized AuNPs illustrate perfect chemical stability for more than 24 weeks in an aqueous solution. Therefore, the size of DNBA-AuNP was smaller and most stable than SA-AuNP, which may be due to 2 nitro groups that have resonance with the benzene ring leading to an increase in the stability of AuNPs.The stability of AuNPs in this work was monitored at a range of pH 2-12. Where high stability was showed at pH 6.6 ± 0.5, while the aggregation appears at more than pH 10 and less than pH.3.5.Herein, in this paper AuNPs have shown remarkable results against multi-drug resistance Pseudomonas aeruginosa. AuNP functionalized by SA ligand is shown to have a greater biological effect and be more effective than DNBA-AuNP. Due to the high stability of AuNP prepared in this work, it can be further tested to be an improved choice for more biomedical applications in the future.

A series of enantiopure tridentate ligands based on 1,2‐diphenylethane‐1,2‐diamine, containing additional pyridine groups are prepared and applied in asymmetric transfer hydrogenation of ketones.

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