The graviola impact on human astroglioma cells: functional significance of MUDENG

Gopal, Judy; Lee, Yoon-Mi; Shin, Juhyun; Muthu, Manikandan; Jung, Seunghwa; Jeong, So-Mi; Oh, Jeongheon; Oh, Jae-Wook

doi:10.1039/c8ra10039j

Cited by 5 publications

(3 citation statements)

References 50 publications

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“…Furthermore, we have reported that MuD possesses anti-apoptotic functions [18], and is involved in silver nanoparticle (AgNP)-induced astroglioma hormesis [19]. In addition, we reported the correlation between graviola anti-cancer activity and MuD [20].…”

Section: Introductionmentioning

confidence: 91%

Cytotoxic and apoptotic potential of Phyllodium elegans extracts on human cancer cell lines

Jung

Shin

et al. 2019

Bioengineered

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The extract of Phyllodium (P.) elegans was investigated for its anti-cancer properties on brain astroglioma cells (U251-MG), colorectal carcinoma cells (HCT116), and malignant melanoma cells (A375). P. elegans methanolic extract (PeME) showed cytotoxicity on all three cancer cell lines tested. The cell viability assay revealed that PeME significantly reduced the viability of these cells. Clear apoptotic features such as cellular morphology, cell shrinkage, and augmentation of dead cells were observed. Flow cytometry and fluorescence staining techniques confirmed the apoptotic property of PeME. In vitro scratch invasion assay showed that cell migration rate was significantly reduced. Fluorescence microscopic studies using 4′,6-diamidino-2-phenylindole staining showed early and late signs of apoptosis after PeME treatment. Upon PeME stimulation, activation of caspase-3/-9 and Mu-2-related death-inducing gene (MUDENG, MuD) was observed by western blot analysis. JC-1 staining analysis by flow cytometry showed that PeME depolarized the mitochondria membrane potential (MMP). Collectively, these findings, for the first time, point to the fact that PeME has anti-cancer properties against brain, colon, and skin cancer cell lines by depolarizing the MMP and activating apoptotic signaling through the activation of caspase-3/-9 as well as MuD. This is the first report reporting the anticancer activity of this specific plant extract.

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Section: Introductionmentioning

confidence: 91%

Cytotoxic and apoptotic potential of Phyllodium elegans extracts on human cancer cell lines

Jung

Shin

et al. 2019

Bioengineered

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“…The release profiles of the AME extract from the electrospun fiber scaffolds were studied using a UV-Vis spectrophotometer (UV-3010, Hitachi, Tokyo, Japan) at an optical wavelength of 210 nm. 26,27 This wavelength was chosen after 10 scans of randomized samples produced distinctive absorption peaks (λ max ) at 210 nm that is characteristic of acetogenins in the leaf of AME. 12 A standard curve for tenfold serial dilutions of the AME extract was prepared using Beer-Lambert's law.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

In vitro studies of Annona muricata L. extract‐loaded electrospun scaffolds for localized treatment of breast cancer

et al. 2021

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This paper presents in vitro studies of the sustained release of Annona muricata leaf extracts (AME) from hybrid electrospun fibers for breast cancer treatment.Electrospun hybrid scaffolds were fabricated from crude AME extracts, poly(lacticco-glycolic acid)/gelatin (PLGA/Ge) and pluronic F127. The physicochemical properties of the AME extract and scaffolds were studied. The antiproliferative effects of the scaffolds were also assessed on breast cancer (MCF-7 and MDA-MB-231) and non-tumorigenic breast (MCF10A) cell lines. Scanning electron microscope micrographs revealed a random network of micro-and submicron fibers. In vitro drug release profiles, governed by quasi-Fickian diffusion at pH 7.

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“…Oh et al [ 106 ] have also reported the anti-astroglioma effect of Graviola extracts from a MuD perspective: extracts from Graviola leaves, fruits, and seeds against human astroglioma cells. Graviola is established for its anti-cancer effect [ 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 ].…”

Section: Evolution Of Mudengmentioning

confidence: 99%

The MUDENG Augmentation: A Genesis in Anti-Cancer Therapy?

Muthu

Chun

Gopal

et al. 2020

IJMS

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Despite multitudes of reports on cancer remedies available, we are far from being able to declare that we have arrived at that defining anti-cancer therapy. In recent decades, researchers have been looking into the possibility of enhancing cell death-related signaling pathways in cancer cells using pro-apoptotic proteins. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and Mu-2/AP1M2 domain containing, death-inducing (MUDENG, MuD) have been established for their ability to bring about cell death specifically in cancer cells. Targeted cell death is a very attractive term when it comes to cancer, since most therapies also affect normal cells. In this direction TRAIL has made noteworthy progress. This review briefly sums up what has been done using TRAIL in cancer therapeutics. The importance of MuD and what has been achieved thus far through MuD and the need to widen and concentrate on applicational aspects of MuD has been highlighted. This has been suggested as the future perspective of MuD towards prospective progress in cancer research.

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The graviola impact on human astroglioma cells: functional significance of MUDENG

Abstract: Graviola (Annona muricate) is a coveted tropical plant that has been found to be effective against many human cancers.

Cited by 5 publications

References 50 publications

Cytotoxic and apoptotic potential of Phyllodium elegans extracts on human cancer cell lines

Cytotoxic and apoptotic potential of Phyllodium elegans extracts on human cancer cell lines

In vitro studies of Annona muricata L. extract‐loaded electrospun scaffolds for localized treatment of breast cancer

The MUDENG Augmentation: A Genesis in Anti-Cancer Therapy?

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